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Advances in the biotechnological glycosylation of valuable flavonoids
Jianbo Xiao1,2,3; Tamar S. Muzashvili4; Milen I. Georgiev5
Source PublicationBiotechnology advances

The natural flavonoids, especially their glycosides, are the most abundant polyphenols in foods and have diverse bioactivities. The biotransformation of flavonoid aglycones into their glycosides is vital in flavonoid biosynthesis. The main biological strategies that have been used to achieve flavonoid glycosylation in the laboratory involve metabolic pathway engineering and microbial biotransformation. In this review, we summarize the existing knowledge on the production and biotransformation of flavonoid glycosides using biotechnology, as well as the impact of glycosylation on flavonoid bioactivity. Uridine diphosphate glycosyltransferases play key roles in decorating flavonoids with sugars. Modern metabolic engineering and proteomic tools have been used in an integrated fashion to generate numerous structurally diverse flavonoid glycosides. In vitro, enzymatic glycosylation tends to preferentially generate flavonoid 3- and 7-O-glucosides; microorganisms typically convert flavonoids into their 7-O-glycosides and will produce 3-O-glycosides if supplied with flavonoid substrates having a hydroxyl group at the C-3 position. In general, O-glycosylation reduces flavonoid bioactivity. However, C-glycosylation can enhance some of the benefits of flavonoids on human health, including their antioxidant and anti-diabetic potential.

KeywordFlavonoid Aglycones Glycosides Glycosylation Glycosyltransferases Microbial Biotransformation Metabolic Engineering
Indexed BySCI
WOS Research AreaBiotechnology & Applied Microbiology
WOS SubjectBiotechnology & Applied Microbiology
WOS IDWOS:000342253100010
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Cited Times [WOS]:122   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorJianbo Xiao
Affiliation1.Department of Biology, Shanghai Normal University, 100 Guilin Rd, Shanghai 200234, China
2.nstitut für Pharmazie und Lebensmittelchemie, Universität Würzburg, Am Hubland, 97074 Würzburg, Germany
3.Anhui Academy of Applied Technology, Suixi Road 312, 230031 Hefei, Anhui, China
4.Iovel Kutateladze Institute of Pharmacochemistry, Tbilisi State Medical University, 36 P. Sarajishvili st., 0159 Tbilisi, Georgia
5.The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, 139 Ruski Blvd., 4000 Plovdiv, Bulgaria
Recommended Citation
GB/T 7714
Jianbo Xiao,Tamar S. Muzashvili,Milen I. Georgiev. Advances in the biotechnological glycosylation of valuable flavonoids[J]. Biotechnology advances,2014,32(6):1145-1156.
APA Jianbo Xiao,Tamar S. Muzashvili,&Milen I. Georgiev.(2014).Advances in the biotechnological glycosylation of valuable flavonoids.Biotechnology advances,32(6),1145-1156.
MLA Jianbo Xiao,et al."Advances in the biotechnological glycosylation of valuable flavonoids".Biotechnology advances 32.6(2014):1145-1156.
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