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Self‐Assembled Metal‐Phenolic Nanoparticles for Enhanced Synergistic Combination Therapy against Colon Cancer
Ke Li1; Yunlu Dai2; Wen Chen3; Kang Yu1; Gao Xiao4,5; Joseph J. Richardson6; Wen Huang7; Junling Guo1,5; Xuepin Liao1; Bi Shi1
2018-11-20
Source PublicationAdvanced Biosystems
ISSN2366-7478
Issue1800241
Abstract

Engineering functional nanomaterials to have both high therapeutic efficacy and minimal side‐effects has become a promising strategy for next‐generation cancer treatments. Herein, an adenosine triphosphate (ATP) depletion and reactive oxygen species‐enhanced combination chemotherapy platform is introduced whereby therapeutic samarium (Sm3+) ions and (−)‐epicatechin (EC) are integrated via a metal‐phenolic network (SmIII‐EC). The independent pathway between Sm3+ and EC can achieve a synergistic therapeutic effect through the mitochondrial dysfunction process. SmIII‐EC nanoparticles cause a significant reduction of viability of C26 murine colon carcinoma cells while with lower systemic toxic effects on normal cell lines. SmIII‐EC nanoparticles are used to directly compare with a clinic anticancer drug 5‐fluorouracil. SmIII‐EC nanoparticles not only decrease the tumor volume but also do not affect the body weight of mice and normal organs, showing significant advantages over clinic counterpart. These facts suggest that SmIII‐EC nanoparticles represent a clinically promising candidate for colon cancer treatment with a targeted therapeutic effect and minimum side toxicity.

KeywordColon Cancer Combination Therapy Metal‐phenolic Networks Rare Earth Ros
DOIhttps://doi.org/10.1002/adbi.201800241
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Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorJunling Guo; Xuepin Liao
Affiliation1.Department of Biomass Science and Engineering, Sichuan University, , Chengdu, 610065 China
2.Faculty of Health Sciences, University of Macau, , Macau SAR, 999078 China
3.Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, , Boston, MA, 02115 USA
4.Department of Environmental Science and Engineering, College of Environment and Resources, Fuzhou University, , Fuzhou, 350108 China
5.Wyss Institute for Biologically Inspired Engineering, John A. Paulson School of Engineering and Applied Sciences, Harvard University, , Boston, MA, 02115 USA
6.ARC Centre of Excellence in Convergent Bio‐Nano Science and Technology and Department of Chemical Engineering, The University of Melbourne, , Parkville, Victoria, 3010 Australia
7.Laboratory of Ethnopharmacology, Regenerative Medicine Research Center, West China Hospital, Sichuan University, , Chengdu, Sichuan, 610041 China
Recommended Citation
GB/T 7714
Ke Li,Yunlu Dai,Wen Chen,et al. Self‐Assembled Metal‐Phenolic Nanoparticles for Enhanced Synergistic Combination Therapy against Colon Cancer[J]. Advanced Biosystems,2018(1800241).
APA Ke Li.,Yunlu Dai.,Wen Chen.,Kang Yu.,Gao Xiao.,...&Bi Shi.(2018).Self‐Assembled Metal‐Phenolic Nanoparticles for Enhanced Synergistic Combination Therapy against Colon Cancer.Advanced Biosystems(1800241).
MLA Ke Li,et al."Self‐Assembled Metal‐Phenolic Nanoparticles for Enhanced Synergistic Combination Therapy against Colon Cancer".Advanced Biosystems .1800241(2018).
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