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Potential therapeutic targets of triple-negative breast cancer based on its intrinsic subtype
Shao, Fangyuan; Sun, Heng; Deng, Chu-Xia
2017-09-22
Source PublicationONCOTARGET
ISSN1949-2553
Volume8Issue:42Pages:73329-73344
Abstract

Triple-negative breast cancer (TNBC) is an aggressive subgroup of human breast cancer, which is characterized as estrogen receptor (ER) negative, progesterone receptor (PR) negative, and human epidermal growth factor receptor 2 (HER2) negative. TNBC is the most difficult breast cancer subgroup to treat, due to its unresponsiveness to current clinical targeted therapies, high rate of recurrence, and poor prognosis. Thus, there is an urgent medical need to identify therapeutic targets and develop more effective stratified medicine for the treatment of TNBC. Here we review the potential therapeutic targets for TNBC based on its intrinsic subtype. We also review the aberrant activated signals found in different subgroups of TNBC, including androgen receptor (AR) and PI3K/AKT/mTOR, Notch, Wnt/beta-catenin, Hedge-hog, and TGF-beta signaling pathways, which play essential roles in multiple development stages of TNBC. The careful analysis of these signaling pathways and therapeutic targets would have significant impact on the drug development and clinical trials, leading to effective therapies for this deadly disease.

KeywordCancer Therapy Tnbc Subtype Cscs Drug Resistance Cancer Targets
DOIhttp://doi.org/10.18632/oncotarget.20274
URLView the original
Indexed BySCI
Language英语
WOS Research AreaOncology ; Cell Biology
WOS SubjectOncology ; Cell Biology
WOS IDWOS:000411509400160
PublisherIMPACT JOURNALS LLC
The Source to ArticleWOS
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Citation statistics
Cited Times [WOS]:25   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorDeng, Chu-Xia
AffiliationFaculty of Health Sciences, University of Macau, Macau SAR, China
First Author AffilicationFaculty of Health Sciences
Corresponding Author AffilicationFaculty of Health Sciences
Recommended Citation
GB/T 7714
Shao, Fangyuan,Sun, Heng,Deng, Chu-Xia. Potential therapeutic targets of triple-negative breast cancer based on its intrinsic subtype[J]. ONCOTARGET,2017,8(42):73329-73344.
APA Shao, Fangyuan,Sun, Heng,&Deng, Chu-Xia.(2017).Potential therapeutic targets of triple-negative breast cancer based on its intrinsic subtype.ONCOTARGET,8(42),73329-73344.
MLA Shao, Fangyuan,et al."Potential therapeutic targets of triple-negative breast cancer based on its intrinsic subtype".ONCOTARGET 8.42(2017):73329-73344.
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