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The Candida albicans transcription factor Cas5 couples stress responses, drug resistance and cell cycle regulation
Xie, Jinglin L.1; Qin, Longguang2; Miao, Zhengqiang2; Grys, Ben T.1,3; Diaz, Jacinto De La Cruz4; Ting, Kenneth1; Krieger, Jonathan R.5; Tong, Jiefei6; Tan, Kaeling2; Leach, Michelle D.1,7; Ketela, Troy1; Moran, Michael F.1,5,6; Krysan, Damian J.4,8; Boone, Charles1,3; Andrews, Brenda J.1,3; Selmecki, Anna9; Wong, Koon Ho2; Robbins, Nicole1; Cowen, Leah E.1
2017-09-11
Source PublicationNATURE COMMUNICATIONS
ISSN2041-1723
Volume8
Abstract

The capacity to coordinate environmental sensing with initiation of cellular responses underpins microbial survival and is crucial for virulence and stress responses in microbial pathogens. Here we define circuitry that enables the fungal pathogen Candida albicans to couple cell cycle dynamics with responses to cell wall stress induced by echinocandins, a front-line class of antifungal drugs. We discover that the C. albicans transcription factor Cas5 is crucial for proper cell cycle dynamics and responses to echinocandins, which inhibit beta-1,3-glucan synthesis. Cas5 has distinct transcriptional targets under basal and stress conditions, is activated by the phosphatase Glc7, and can regulate the expression of target genes in concert with the transcriptional regulators Swi4 and Swi6. Thus, we illuminate a mechanism of transcriptional control that couples cell wall integrity with cell cycle regulation, and uncover circuitry governing antifungal drug resistance.

DOI10.1038/s41467-017-00547-y
URLView the original
Indexed BySCI
Language英语
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000410237600001
PublisherNATURE PUBLISHING GROUP
The Source to ArticleWOS
Fulltext Access
Citation statistics
Cited Times [WOS]:16   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.Department of Molecular Genetics, University of Toronto, Toronto, ON Canada M5G 1M1
2.Faculty of Health Sciences, University of Macau, Macau SAR, 999078 China
3.Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON Canada M5S 3E1
4.Department of Microbiology and Immunology, University of Rochester, Rochester, NY 14642 USA
5.The Hospital for Sick Children, SPARC Biocentre, Toronto, ON Canada M5G 0A4
6.The Hospital for Sick Children, Program in Cell Biology, Peter Gilgan Centre for Research and Learning, Toronto, ON Canada M5G 0A4
7.Aberdeen Fungal Group, School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Abderdeen AB252ZD UK
8.Department of Pediatrics and Microbiology/Immunology, University of Rochester, Rochester, NY 14642 USA
9.Department of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, NE 68178 USA
Recommended Citation
GB/T 7714
Xie, Jinglin L.,Qin, Longguang,Miao, Zhengqiang,et al. The Candida albicans transcription factor Cas5 couples stress responses, drug resistance and cell cycle regulation[J]. NATURE COMMUNICATIONS,2017,8.
APA Xie, Jinglin L..,Qin, Longguang.,Miao, Zhengqiang.,Grys, Ben T..,Diaz, Jacinto De La Cruz.,...&Cowen, Leah E..(2017).The Candida albicans transcription factor Cas5 couples stress responses, drug resistance and cell cycle regulation.NATURE COMMUNICATIONS,8.
MLA Xie, Jinglin L.,et al."The Candida albicans transcription factor Cas5 couples stress responses, drug resistance and cell cycle regulation".NATURE COMMUNICATIONS 8(2017).
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