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Ervadivamines A and B, Two Unusual Trimeric Monoterpenoid Indole Alkaloids from Ervatamia divaricata
Liu, Zhi-Wen1; Zhang, Jian1,2; Li, Song-Tao1; Liu, Ming-Qun1; Huang, Xiao-Jun1; Ao, Yun-Lin1; Fan, Chun-Lin1; Zhang, Dong-Mei1; Zhang, Qing-Wen2; Ye, Wen-Cai1; Zhang, Xiao-Qi1
2018-09-07
Source PublicationJOURNAL OF ORGANIC CHEMISTRY
ISSN0022-3263
Volume83Issue:17Pages:10613-10618
Abstract

Ervadivamines A (1) and B (2), two unprecedented trimeric monoterpenoid indole alkaloids, were isolated from Ervatamia divaricata. They are the first examples of vobasine-iboga-vobasine-type alkaloid with both C-C and C-N linkage patterns. Their structures including absolute configurations were fully accomplished by extensive spectroscopic analysis, single-crystal X-ray diffraction, and electric circular dichroism methods. The plausible biogenetic pathways of these trimeric alkaloids were also proposed. In addition, compound 1 exhibited significant cytotoxicity against four cancer cells.

DOI10.1021/acs.joc.8b01371
URLView the original
Indexed BySCI
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Organic
WOS IDWOS:000444364600097
PublisherAMER CHEMICAL SOC
The Source to ArticleWOS
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Cited Times [WOS]:9   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.Institute of Traditional Chinese Medicine and Natural Products, and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou 510632, P. R. China
2.State Key Laboratory of Quality Research in Chinese
Recommended Citation
GB/T 7714
Liu, Zhi-Wen,Zhang, Jian,Li, Song-Tao,et al. Ervadivamines A and B, Two Unusual Trimeric Monoterpenoid Indole Alkaloids from Ervatamia divaricata[J]. JOURNAL OF ORGANIC CHEMISTRY,2018,83(17):10613-10618.
APA Liu, Zhi-Wen.,Zhang, Jian.,Li, Song-Tao.,Liu, Ming-Qun.,Huang, Xiao-Jun.,...&Zhang, Xiao-Qi.(2018).Ervadivamines A and B, Two Unusual Trimeric Monoterpenoid Indole Alkaloids from Ervatamia divaricata.JOURNAL OF ORGANIC CHEMISTRY,83(17),10613-10618.
MLA Liu, Zhi-Wen,et al."Ervadivamines A and B, Two Unusual Trimeric Monoterpenoid Indole Alkaloids from Ervatamia divaricata".JOURNAL OF ORGANIC CHEMISTRY 83.17(2018):10613-10618.
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