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The Typical Metabolic Modifiers Conferring Improvement in Cancer Resistance
Tan, Wen1; Zhong, Zhangfeng2; Wang, Shengpeng2; Liu, Hui1; Yu, Hua2; Tan, Rui3; Hu, Xiaodong1; Pan, Tingrui4; Wang, Yitao2
2017
Source PublicationCURRENT MEDICINAL CHEMISTRY
ISSN0929-8673
Volume24Issue:34Pages:3698-3710
Abstract

Background: Cancer metabolic reprogramming rekindles enthusiasm for the research of metabolic regulation in cancer drug resistance. A growing number of metabolic modifiers combined with cancer drugs obtain the expected efficacy in in vitro or in vivo studies, also in clinical trial studies, indicating a good potential of enhancing efficacy and reducing resistance. Hence, a comprehensive review on the attenuations of metabolic modifiers in cancer drug resistance is necessary for rational drug design and clinical cancer drug research.

Methods: Cancer drug resistance and cancer metabolic reprogramming were used as the key words to collect publications with reference value in bibliographic databases. Specifically, the focused question is the advances of metabolic modifiers on cancer resistance improvement. Figures and tables were applied to analyze the interventions in accordance with the inclusion criteria.

Results: This review summarized the advances of metabolic modifiers combined with cancer drugs in in vitro, in vivo and clinical trial studies, especially for cancer resistance improvement. The relationship between metabolic regulation and cancer resistance was elaborated, and the potential metabolic modifiers were embraced. Metabolic targets were also visualized in categorization in 4 figures and expatiated in 4 tables. Three typical metabolic modifiers, namely lonidamine, 2-DG and 3-BrPA, conferring attenuation to cancer resistance were elucidated systematically.

Conclusion: Metabolic regulation is an intervention with targeted perturbation in a modest manner and reflects homeostasis balance. When combined with cancer drugs, the metabolic modifiers always show exciting potential with practical significance, enhancing activity or exerting synergism.

KeywordCancer Resistance Cancer Metabolic Reprogramming Metabolic Modifiers Lonidamine 2-deoxy-d-glucose 3-bromopyruvate
DOIhttp://doi.org/10.2174/0929867324666170203121449
URLView the original
Indexed BySCI
Language英语
WOS Research AreaBiochemistry & Molecular Biology ; Pharmacology & Pharmacy
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS IDWOS:000415618800003
PublisherBENTHAM SCIENCE PUBL LTD
The Source to ArticleWOS
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Cited Times [WOS]:8   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.School of Pharmacy, Lanzhou University, Lanzhou, Gansu province, China
2.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China
3.College of Medicine, Southwest Jiaotong University, Chengdu, Sichuan province, China
4.Micro-Nano Innovations (MiNI) Laboratory, Department of Biomedical Engineering, University of California, Davis, United States
Recommended Citation
GB/T 7714
Tan, Wen,Zhong, Zhangfeng,Wang, Shengpeng,et al. The Typical Metabolic Modifiers Conferring Improvement in Cancer Resistance[J]. CURRENT MEDICINAL CHEMISTRY,2017,24(34):3698-3710.
APA Tan, Wen.,Zhong, Zhangfeng.,Wang, Shengpeng.,Liu, Hui.,Yu, Hua.,...&Wang, Yitao.(2017).The Typical Metabolic Modifiers Conferring Improvement in Cancer Resistance.CURRENT MEDICINAL CHEMISTRY,24(34),3698-3710.
MLA Tan, Wen,et al."The Typical Metabolic Modifiers Conferring Improvement in Cancer Resistance".CURRENT MEDICINAL CHEMISTRY 24.34(2017):3698-3710.
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