UM  > 個人在本單位外知識產出
Effect of betamethasone on neuropathic pain and cerebral expression of NF-κB and cytokines
Xie,Weiying1; Liu,Xiaoming1; Xuan,Haojun2; Luo,Saizhen3; Zhao,Xin4; Zhou,Zhiqiang1; Xu,Jianguo1
Source PublicationNeuroscience Letters
AbstractGlucocorticoids have been used to treat neuropathic pain for many years, but the underlying mechanisms are still unknown. Recent studies indicate that pathological pain states may be mediated by cytokines. We, therefore, examined the effect of betamethasone on neuropathic pain and the relationship between pain behavior and the expression of cytokines in the brain. Rats were given epidural injections of betamethasone (Diprospan) after L5 spinal nerve transection. Mechanical allodynia and thermal hyperalgesia were evaluated on post-operative days 1, 3, 7, 14 and 21 with von Frey and Hargreaves tests. Cerebral expression of NF-κB, TNFα, IL-1β and IL-10 was quantified using electrophoretic mobility shift assay (EMSA) or enzyme-linked immunosorbent assay (ELISA). We found that spinal nerve injury caused long-lasting mechanical and thermal hyperalgesia in the hind paw and stimulated the expression of NF-κB, TNFα, IL-1β and IL-10 in the brain. A single epidural injection of betamethasone at the time of nerve injury partially inhibited the development of neuropathic hyperalgesia and reduced the subsequent elevated levels of pro-inflammatory cytokines in the brain, while stimulating the expression of the anti-inflammatory cytokine IL-10. These data support our hypothesis that pro-inflammatory cytokines in the brain may mediate the hyperalgesic effects of spinal nerve injury and that the long-acting anti-hyperalgesic effects of epidural glucocorticoid treatment are due to an inhibitory effect on pro-inflammatory cytokine levels and a stimulatory effect on anti-inflammatory cytokine levels in the brain. © 2005 Elsevier Ireland Ltd. All rights reserved.
KeywordBetamethasone IL-1β IL-10 Neuropathic pain NF-κB TNFα
URLView the original
Fulltext Access
Citation statistics
Cited Times [WOS]:38   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionPersonal research not belonging to the institution
Affiliation1.Department of Anaesthesiology,Jinling Hospital,Nanjing University,,China
2.Department of Cardiothoracic Surgery,Tongde Hospital of Zhejiang Province,,China
3.College of Science,Nanchang University,,China
4.Department of Anaesthesiology,Ruijin Hospital,,China
Recommended Citation
GB/T 7714
Xie,Weiying,Liu,Xiaoming,Xuan,Haojun,et al. Effect of betamethasone on neuropathic pain and cerebral expression of NF-κB and cytokines[J]. Neuroscience Letters,2006,393(2-3):255-259.
APA Xie,Weiying.,Liu,Xiaoming.,Xuan,Haojun.,Luo,Saizhen.,Zhao,Xin.,...&Xu,Jianguo.(2006).Effect of betamethasone on neuropathic pain and cerebral expression of NF-κB and cytokines.Neuroscience Letters,393(2-3),255-259.
MLA Xie,Weiying,et al."Effect of betamethasone on neuropathic pain and cerebral expression of NF-κB and cytokines".Neuroscience Letters 393.2-3(2006):255-259.
Related Services
Recommend this item
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Xie,Weiying]'s Articles
[Liu,Xiaoming]'s Articles
[Xuan,Haojun]'s Articles
Baidu academic
Similar articles in Baidu academic
[Xie,Weiying]'s Articles
[Liu,Xiaoming]'s Articles
[Xuan,Haojun]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Xie,Weiying]'s Articles
[Liu,Xiaoming]'s Articles
[Xuan,Haojun]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.