UM  > 中華醫藥研究院
The anti-inflammatory potential of Portulaca oleracea L. (purslane) extract by partial suppression on NF-kappa B and MAPK activation
Lingchao Miao1; Hongxun Tao1; Yu Peng1; Shengpeng Wang1; Zhangfeng Zhong1; Hesham El-Seedi2; Simona Dragan3; Gokhan Zengin4; Wai San Cheang1; Yitao Wang1; Jianbo Xiao1
2019-04-02
Source PublicationFOOD CHEMISTRY
ISSN0308-8146
Volume290Pages:239-245
Abstract

Portulaca oleracea L. (Purslane) has great potential as food and traditional drugs in several countries. The purpose of this study was to evaluate the anti-inflammatory effects of purslane extract on lipopolysaccharide (LPS)- stimulated RAW 264.7 cells. Purslane extracts significantly reduced LPS-induced synthesis of NO in a dosedependent manner, as well as the expression levels of iNOS and COX-2. The productions of TNF-α and IL-6 were also significantly reduced at the higher dose of 400 μg/ml. Meanwhile, the expression levels of P65, p-P65, pMEK and p-IκB-α were inhibited dose-dependently. The nuclear translocation of P65 was partially prevented by the extract, which explained the inhibition of NF-κB pathway. In addition, three reported flavonoids, named luteolin, kaempferol and quercitrin, were identified in the extract, which might be responsible for its antiinflammatory effects. Above all, our research has partially proved that purslane could be considered as a natural anti-inflammatory agent in further applications.

KeywordPortuL.ca OL.racea L. Flavonoids Lipopolysaccharide Anti-inflammatory Effects Nf-κb Mapk
DOI10.1016/j.foodchem.2019.04.005
Indexed BySCI
Language英语
WOS Research AreaChemistry ; Food Science & Technology ; Nutrition & Dietetics
WOS SubjectChemistry, Applied ; Food Science & Technology ; Nutrition & Dietetics
WOS IDWOS:000464920800030
PublisherELSEVIER SCI LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
Fulltext Access
Citation statistics
Cited Times [WOS]:9   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorYitao Wang; Jianbo Xiao
Affiliation1.State Key Laboratory of Quality Control in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau
2.Department of Medicinal Chemistry, Uppsala University, Biomedical Centre, Box 574, SE-75 123 Uppsala, Sweden
3.University of Medicine and Pharmacy Victor Babes, 2 Eftimie Murgu Sq, 300041 Timisoara, Romania
4.Department of Biology, Science Faculty, Selcuk University, Konya, Turkey
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Lingchao Miao,Hongxun Tao,Yu Peng,et al. The anti-inflammatory potential of Portulaca oleracea L. (purslane) extract by partial suppression on NF-kappa B and MAPK activation[J]. FOOD CHEMISTRY,2019,290:239-245.
APA Lingchao Miao.,Hongxun Tao.,Yu Peng.,Shengpeng Wang.,Zhangfeng Zhong.,...&Jianbo Xiao.(2019).The anti-inflammatory potential of Portulaca oleracea L. (purslane) extract by partial suppression on NF-kappa B and MAPK activation.FOOD CHEMISTRY,290,239-245.
MLA Lingchao Miao,et al."The anti-inflammatory potential of Portulaca oleracea L. (purslane) extract by partial suppression on NF-kappa B and MAPK activation".FOOD CHEMISTRY 290(2019):239-245.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Lingchao Miao]'s Articles
[Hongxun Tao]'s Articles
[Yu Peng]'s Articles
Baidu academic
Similar articles in Baidu academic
[Lingchao Miao]'s Articles
[Hongxun Tao]'s Articles
[Yu Peng]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Lingchao Miao]'s Articles
[Hongxun Tao]'s Articles
[Yu Peng]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.