UM  > 中華醫藥研究院
Monodisperse molecularly imprinted microsphere cartridges coupled with HPLC for selective analysis of dexamethasone and hydrocortisone in cosmetics by using matrix solid-phase dispersion
Pengqi Guo1,2,3; Guoning Chen2; Hua Shu2; Peng Li3; Pei Yu4; Chun Chang2; Yitao Wang3; Qiang Fu2
2019-06-20
Source PublicationANALYTICAL METHODS
ISSN1759-9660
Volume11Issue:29Pages:3687-3696
Abstract

The illegal addition of glucocorticoids to cosmetics can cause serious adverse reactions. For the selective determination of glucocorticoids in cosmetics, a simple, fast and sensitive method for the determination of dexamethasone and hydrocortisone has been developed by combining selective monodisperse molecularly imprinted microsphere matrix solid-phase dispersion and high performance liquid chromatography (MMIM-MSPD-HPLC). The prepared molecularly imprinted monodisperse microspheres have excellent specific affinity for dexamethasone and hydrocortisone and the obtained extract was thoroughly cleaned and can be directly subjected to HPLC for analysis without matrix interference. The established MMIM-MSPD-HPLC method was validated and successfully used for detecting dexamethasone and hydrocortisone in cosmetic samples with good selectivity, sensitivity and efficiency. The linear range was 0.05 to 50 mg g1 with a limit of detection of 0.03 mg g1 for dexamethasone and 0.02 mg g1 for hydrocortisone, respectively. The RSD values of intra-day precision and inter-day precision are less than 6.52%. Compared with other literature methods, the established method has the advantages of accuracy, selectivity and specificity.

DOI10.1039/c9ay01196j
Indexed BySCI
Language英语
WOS Research AreaChemistry ; Food Science& Technology ; Spectroscopy
WOS SubjectChemistry, Analytical ; Food Science & Technology ; Spectroscopy
WOS IDWOS:000477061800007
PublisherROYAL SOC CHEMISTRY, THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND
Fulltext Access
Citation statistics
Cited Times [WOS]:3   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorQiang Fu
Affiliation1.School of Chemical Engineering, Northwest University, Xi'an, PR China
2.School of Pharmacy, Xi'an Jiaotong University, Xi'an, PR China.
3.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, PR China
4.School of Medicine, Xi'an International University, Xi'an, PR China
First Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Pengqi Guo,Guoning Chen,Hua Shu,et al. Monodisperse molecularly imprinted microsphere cartridges coupled with HPLC for selective analysis of dexamethasone and hydrocortisone in cosmetics by using matrix solid-phase dispersion[J]. ANALYTICAL METHODS,2019,11(29):3687-3696.
APA Pengqi Guo.,Guoning Chen.,Hua Shu.,Peng Li.,Pei Yu.,...&Qiang Fu.(2019).Monodisperse molecularly imprinted microsphere cartridges coupled with HPLC for selective analysis of dexamethasone and hydrocortisone in cosmetics by using matrix solid-phase dispersion.ANALYTICAL METHODS,11(29),3687-3696.
MLA Pengqi Guo,et al."Monodisperse molecularly imprinted microsphere cartridges coupled with HPLC for selective analysis of dexamethasone and hydrocortisone in cosmetics by using matrix solid-phase dispersion".ANALYTICAL METHODS 11.29(2019):3687-3696.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Pengqi Guo]'s Articles
[Guoning Chen]'s Articles
[Hua Shu]'s Articles
Baidu academic
Similar articles in Baidu academic
[Pengqi Guo]'s Articles
[Guoning Chen]'s Articles
[Hua Shu]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Pengqi Guo]'s Articles
[Guoning Chen]'s Articles
[Hua Shu]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.