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Overview of pharmacological activities of Andrographis paniculata and its major compound andrographolide
Yan Dai1; Shao-Ru Chen1; Ling Chai2; Jing Zhao1; Yitao Wang1; Ying Wang1
2018-09-10
Source PublicationCRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
ISSN1040-8398
Volume59Pages:S17-S29
Abstract

Andrographis paniculata (A. paniculata) is a medicinal plant traditionally used as anti-inflammation and anti-bacteria herb. Andrographolide, the major active component of A. paniculata, exhibits diverse pharmacological activities, including anti-inflammation, anti-cancer, anti-obesity, anti-diabetes, and other activities. In this article, we comprehensively review the therapeutic potential of A. paniculata and andrographolide focusing on the mechanisms of action and clinical application. We systemically discuss the structure-activity relationship of andrographolide and derivatives. Despite the various pharmacological activities and formula of A. paniculata and andrographolide, we propose further development of more structural derivatives of andrographolide with reduced toxicity and increased therapeutic efficacy is still needed for the clinical application of this ancient mighty herb and its major component.

KeywordAndrographis Paniculata Andrographolide Mechanisms Of Action Structureactivity-relationship
DOI10.1080/10408398.2018.1501657
Indexed BySCI
Language英语
WOS Research AreaFood Science & Technology ; Nutrition & Dietetics
WOS SubjectFood Science & Technology ; Nutrition & Dietetics
WOS IDWOS:000470673800003
PublisherTAYLOR & FRANCIS INC, 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
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Cited Times [WOS]:21   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorYitao Wang; Ying Wang
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine and Institute of Chinese Medical Sciences, University of Macau, Avenida da Universidade, Taipa, Macao SAR, China
2.Guangxi Institute of Traditional Medical and Pharmaceutical Sciences and Guangxi Key Laboratory of Traditional Chinese Medicine Quality Standards, Nanning 530022, China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Yan Dai,Shao-Ru Chen,Ling Chai,et al. Overview of pharmacological activities of Andrographis paniculata and its major compound andrographolide[J]. CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION,2018,59:S17-S29.
APA Yan Dai,Shao-Ru Chen,Ling Chai,Jing Zhao,Yitao Wang,&Ying Wang.(2018).Overview of pharmacological activities of Andrographis paniculata and its major compound andrographolide.CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION,59,S17-S29.
MLA Yan Dai,et al."Overview of pharmacological activities of Andrographis paniculata and its major compound andrographolide".CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION 59(2018):S17-S29.
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