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Deciphering the Pharmacological Mechanisms of the Huayu-Qiangshen-Tongbi Formula Through Integrating Network Pharmacology and In Vitro Pharmacological Investigation
Zihao Wang1; Ke-Gang Linghu1; Yuanjia Hu1; Huali Zuo1; Hao Yi2; Shi-Hang Xiong1; Jinjian Lu1; Ging Chan1; Hua Yu1,3,4; Run-Yue Huang2,5
2019-09-23
Source PublicationFRONTIERS IN PHARMACOLOGY
ISSN1663-9812
Volume10
Abstract

Rheumatoid arthritis is a chronic inflammatory autoimmune disease, causing articular and extra-articular dysfunctions among patients, and it could result in irreversible joint damages or disability if untreated. A traditional Chinese medicine formula, Huayu-Qiangshen-Tongbi (HT) formula, has been observed successful in controlling rheumatoid arthritis progression in traditional Chinese medicine clinics. In this study, we conducted a systematic analysis of the HT formula with a purpose of proposing for its potential mechanism of action using network pharmacological methods. The potential targets of the formula were collected and screened according to the topological features of their protein-protein interaction network, and we subsequently validated our prediction results through in vitro experiments. We proposed that the HT formula could interfere with the bone metabolism and the inflammatory pathways of the body. The experimental validation results indicated that HT formula could exhibit anti-inflammatory effects by regulating several signaling pathways specifically the Toll-like receptor signaling pathway, phosphoinositide-3-kinase-Akt signaling pathway, hypoxia-inducible factor 1 signaling pathway, mitogen-activated protein kinase signaling pathway and activator protein 1 signaling pathway.

KeywordRheumatoid Arthritis Network Pharmacology Traditional Chinese Medicine Huayu-qiangshen-tongbi Formula In Vitro Validation
DOI10.3389/fphar.2019.01065
Indexed BySCI
Language英语
WOS Research AreaPharmacology & Pharmacy
WOS SubjectPharmacology & Pharmacy
WOS IDWOS:000487264400001
PublisherFRONTIERS MEDIA SA, AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
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Cited Times [WOS]:1   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorGing Chan; Hua Yu
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, China
2.Department of Rheumatology and Immunology, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China
3.HKBU Shenzhen Research Center, Shenzhen, China
4.School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, Hong Kong
5.Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome, Guangzhou, China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Zihao Wang,Ke-Gang Linghu,Yuanjia Hu,et al. Deciphering the Pharmacological Mechanisms of the Huayu-Qiangshen-Tongbi Formula Through Integrating Network Pharmacology and In Vitro Pharmacological Investigation[J]. FRONTIERS IN PHARMACOLOGY,2019,10.
APA Zihao Wang.,Ke-Gang Linghu.,Yuanjia Hu.,Huali Zuo.,Hao Yi.,...&Run-Yue Huang.(2019).Deciphering the Pharmacological Mechanisms of the Huayu-Qiangshen-Tongbi Formula Through Integrating Network Pharmacology and In Vitro Pharmacological Investigation.FRONTIERS IN PHARMACOLOGY,10.
MLA Zihao Wang,et al."Deciphering the Pharmacological Mechanisms of the Huayu-Qiangshen-Tongbi Formula Through Integrating Network Pharmacology and In Vitro Pharmacological Investigation".FRONTIERS IN PHARMACOLOGY 10(2019).
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