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A novel scalable fabrication process for the production of dissolving microneedle arrays
Hangping Chen1; Biyuan Wu1; Minmin Zhang1; Peipei Yang1; Beibei Yang1; Wanbing Qin1; Qingqing Wang2; Xinguo Wen3; Meiwan Chen4; Guilan Quan1; Xin Pan1; Chuanbin Wu1

Microneedle arrays have emerged as an alternative method for transdermal drug delivery. Although micromolding using a centrifugation method is widely used to prepare microneedles in laboratory, few researchers were focused on manufacturing processes capable of facile scale-up. A novel female mold was initially designed in this study, namely double-penetration female mold (DPFM) with the pinpoints covered by waterproof breather membrane which was beneficial to reduce the influence of gas resistance and solution viscosity. In addition, DPFM-based positive-pressure microperfusion technique (PPPT) was proposed for the scale-up fabrication of dissolving microneedle arrays (DMNA). In this method, polymer solution and base solution were poured into the DPFM by pressure difference, followed by drying and demolding. The results of optimal microscopy and SEM revealed that the obtained microneedles were uniformly distributed conical-shaped needles. The skin penetration test showed that DMNA prepared using PPPT were able to penetrate the rat skin with a high penetration rate. To realize the transition of microneedles fabrication from laboratory to industry, an automatic equipment was further designed in this study. Different from micromolding method using centrifugation, the equipment based on PPPT and DPFM has superiorities in the scale-up fabrication of microneedles in a highly effective, controllable, and scalable way.

KeywordDissolving Microneedle Arrays Double-penetration Female Mold Positive-pressure Microperfusion Techniqu Scale-up Fabrication
Indexed BySCI
WOS Research AreaInstruments & Instrumentation ; Research & Experimental Medicine ; Pharmacology & Pharmacy
WOS SubjectInstruments & Instrumentation ; Medicine, Research & Experimental ; Pharmacology & Pharmacy
WOS IDWOS:000455501900020
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Cited Times [WOS]:4   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.School of Pharmaceutical Sciences,Sun Yat-sen University,Guangzhou,China
2.Department of Pharmacy,Bengbu Medical College,Bengbu,China
3.Guangzhou Neworld Micnanobio Pharmatech Co. Ltd,Guangzhou,China
4.Institute of Chinese Medical Sciences, University of Macau,Macau,China
Recommended Citation
GB/T 7714
Hangping Chen,Biyuan Wu,Minmin Zhang,et al. A novel scalable fabrication process for the production of dissolving microneedle arrays[J]. DRUG DELIVERY AND TRANSLATIONAL RESEARCH,2019,9(1):240-248.
APA Hangping Chen.,Biyuan Wu.,Minmin Zhang.,Peipei Yang.,Beibei Yang.,...&Chuanbin Wu.(2019).A novel scalable fabrication process for the production of dissolving microneedle arrays.DRUG DELIVERY AND TRANSLATIONAL RESEARCH,9(1),240-248.
MLA Hangping Chen,et al."A novel scalable fabrication process for the production of dissolving microneedle arrays".DRUG DELIVERY AND TRANSLATIONAL RESEARCH 9.1(2019):240-248.
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