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Aqueous extract of Salvia miltiorrhiza Bunge-Radix Puerariae herb pair ameliorates diabetic vascular injury by inhibiting oxidative stress in streptozotocin-induced diabetic rats
Wenwen Zhao1,2; Yuan Yuan3; Haiyu Zhao4; Yantao Han1; Xiuping Chen1,2,3
2019-04-29
Source PublicationFOOD AND CHEMICAL TOXICOLOGY
Volume129Pages:97-107
Abstract

Vascular diabetic complications are the leading cause of mortality and morbidity for diabetes. The present study was designed to investigate the protective effect of herb pair Salvia miltiorrhiza Bunge-Radix Puerariae(DG) on diabetic vascular injury induced by streptozotocin. The protective effect of DG was determined by oral ad-ministration of DG (50 and 200 mg/kg) in rats and on high glucose (HG)-induced endothelial injury. DG showed no effect on body weight, fasting blood glucose (FBG) but decreased the serum levels of insulin, nitric oxide(NO), hydrogen peroxide (H2O2), malondialdehyde (MDA), soluble intercellular cell adhesion molecule-1 (s-ICAM-1) and vascular cell adhesion molecule-1 (s-VCAM-1), and increased superoxide dismutase (SOD) and catalase (CAT) levels. The pathological alterations of aorta was improved by DG. Furthermore, the increased expression of ICAM-1,VCAM-1, NOX2, and NOX4 in aorta were inhibited by DG. HG-induced endothelial ROS formation, ICAM-1,VCAM-1, NOX4 expression and monocyte-endothelial adhesion were dramatically sup-pressed by DG as well. In addition, both GKT137831, a NOX4 inhibitor, and PDTC, a NF-κB inhibitor, could significantly inhibited HG-induced ICAM-1, VCAM-1 expression and monocyte-endothelial adhesion. These results suggested that DG improved diabetic vascular injury possibly by reducing oxidative stress, which providesscientific evidence for the application of DG for diabetic vascular therapy.

KeywordDiabetic Vascular Injury Salvia Miltiorrhiza Bunge Radix Puerariae Oxidative Stress Cell Adhesion Molecules
DOIhttps://doi.org/10.1016/j.fct.2019.04.018
Indexed BySCI
Language英语
WOS Research AreaFood Science & Technology ; Toxicology
WOS SubjectFood Science & Technology ; Toxicology
WOS IDWOS:000472686200010
PublisherPERGAMON-ELSEVIER SCIENCE LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
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Cited Times [WOS]:4   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorYantao Han; Xiuping Chen
Affiliation1.Medical College, Qingdao University, Qingdao, 266071, China
2.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao, China
3.Key Lab for Pharmacology of Ministry of Education, Department of Pharmacology, Zunyi Medical College, Zunyi, 563003, China
4.Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Wenwen Zhao,Yuan Yuan,Haiyu Zhao,et al. Aqueous extract of Salvia miltiorrhiza Bunge-Radix Puerariae herb pair ameliorates diabetic vascular injury by inhibiting oxidative stress in streptozotocin-induced diabetic rats[J]. FOOD AND CHEMICAL TOXICOLOGY,2019,129:97-107.
APA Wenwen Zhao,Yuan Yuan,Haiyu Zhao,Yantao Han,&Xiuping Chen.(2019).Aqueous extract of Salvia miltiorrhiza Bunge-Radix Puerariae herb pair ameliorates diabetic vascular injury by inhibiting oxidative stress in streptozotocin-induced diabetic rats.FOOD AND CHEMICAL TOXICOLOGY,129,97-107.
MLA Wenwen Zhao,et al."Aqueous extract of Salvia miltiorrhiza Bunge-Radix Puerariae herb pair ameliorates diabetic vascular injury by inhibiting oxidative stress in streptozotocin-induced diabetic rats".FOOD AND CHEMICAL TOXICOLOGY 129(2019):97-107.
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