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Anti-inflammatory effects of Glycine tabacina extract in LPS-stimulated macrophages and collagen-induced arthritis mice
Yanbei Tu; Kai Wang; Jian-Bo Wan; Chengwei He
2019-11
Source PublicationJOURNAL OF FUNCTIONAL FOODS
ISSN1756-4646
Volume62
Abstract

Glycine tabacina (Labill.) Benth, a renowned Chinese medicinal herb, has been used for treatment of rheumatoid arthritis (RA) and joint infection. This study aimed to investigate inhibitory effect of its ethanol extract (GTE) on RA-associated inflammation. Nine isoflavonoids of twelve ones which were found in G. tabacina roots were identified by UHPLC-DAD-MS/MS. GTE treatment suppressed lipopolysaccharide-stimulated overproduction of nitric oxide, TNF-α and IL-6, and iNOS expression in macrophages. GTE blocked the activation of NF-κB and MAPK pathways, as indicated by reduced levels of phosphorylation of IKKα/β, IκBα, p38, ERK and JNK, and the suppressed nuclear translocation of NF-κB p65. Additionally, GTE administration decreased swelling of arthritic paw and serum TNF-α and IL-1β levels in collagen-induced arthritis (CIA) mice. These results demonstrated that GTE exhibited strong anti-inflammatory and anti-arthritic activities through suppressing NF-κB and MAPK pathways activation in activated macrophages and CIA mice, suggesting the potential applications of this species in RA prevention and treatment as functional food or therapeutic agent.

KeywordGlycine Tabacina Anti-inflammation Raw 264.7 Macrophages Nf-κb Rheumatoid Arthritis
DOI10.1016/j.jff.2019.103528
Indexed BySCI
Language英语
WOS Research AreaFood Science & Technology ; Nutrition & Dietetics
WOS SubjectFood Science & Technology ; Nutrition & Dietetics
WOS IDWOS:000491207500019
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Cited Times [WOS]:2   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
AffiliationState Key Laboratory of Quality Researchin Chinese Medicine,Institute of Chinese Medical Sciences,University of Macau,Taipa,Macao SAR 999078,China
First Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Yanbei Tu,Kai Wang,Jian-Bo Wan,et al. Anti-inflammatory effects of Glycine tabacina extract in LPS-stimulated macrophages and collagen-induced arthritis mice[J]. JOURNAL OF FUNCTIONAL FOODS,2019,62.
APA Yanbei Tu,Kai Wang,Jian-Bo Wan,&Chengwei He.(2019).Anti-inflammatory effects of Glycine tabacina extract in LPS-stimulated macrophages and collagen-induced arthritis mice.JOURNAL OF FUNCTIONAL FOODS,62.
MLA Yanbei Tu,et al."Anti-inflammatory effects of Glycine tabacina extract in LPS-stimulated macrophages and collagen-induced arthritis mice".JOURNAL OF FUNCTIONAL FOODS 62(2019).
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