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Small molecules for fat combustion: targeting obesity
Liu, JX; Wang, YT; Lin, LG
2019
Source PublicationACTA PHARMACEUTICA SINICA B
ISSN2211-3835
VolumeIssue:2Pages:220-236
Abstract

Obesity is increasing in an alarming rate worldwide, which causes higher risks of some diseases, such as type 2 diabetes, cardiovascular diseases, and cancer. Current therapeutic approaches, either pancreatic lipase inhibitors or appetite suppressors, are generally of limited effectiveness. Brown adipose tissue (BAT) and beige cells dissipate fatty acids as heat to maintain body temperature, termed non-shivering thermogenesis; the activity and mass of BAT and beige cells are negatively correlated with overweight and obesity. The existence of BAT and beige cells in human adults provides an effective weight reduction therapy, a process likely to be amenable to pharmacological intervention. Herein, we combed through the physiology of thermogenesis and the role of BAT and beige cells in combating with obesity. We summarized the thermogenic regulators identified in the past decades, targeting G protein-coupled receptors, transient receptor potential channels, nuclear receptors and miscellaneous pathways. Advances in clinical trials were also presented. The main purpose of this review is to provide a comprehensive and up-to-date knowledge from the biological importance of thermogenesis in energy homeostasis to the representative thermogenic regulators for treating obesity. Thermogenic regulators might have a large potential for further investigations to be developed as lead compounds in fighting obesity.

KeywordObesity Thermogenesis Brown Adipose Tissue Beige Cells Uncoupling Protein 1
DOI10.1016/j.apsb.2018.09.007
Indexed BySCI
Language英语
WOS Research AreaPharmacology & Pharmacy
WOS SubjectPharmacology & Pharmacy
WOS IDWOS:000461052500002
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Cited Times [WOS]:5   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
AffiliationState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa999078, Macau
First Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Liu, JX,Wang, YT,Lin, LG. Small molecules for fat combustion: targeting obesity[J]. ACTA PHARMACEUTICA SINICA B,2019,9(2):220-236.
APA Liu, JX,Wang, YT,&Lin, LG.(2019).Small molecules for fat combustion: targeting obesity.ACTA PHARMACEUTICA SINICA B,9(2),220-236.
MLA Liu, JX,et al."Small molecules for fat combustion: targeting obesity".ACTA PHARMACEUTICA SINICA B 9.2(2019):220-236.
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