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A luminescence switch-on assay for the detection of specific gene deletion using G-quadruplex DNA and silver nanoclusters
Wang, MD1; Wang, WH1; Liu, CF1; Liu, JB1; Kang, TS2; Leung, CH2; Ma, DL1
2017
Source PublicationMATERIALS CHEMISTRY FRONTIERS
ISSN2052-1537
Volume1Issue:1Pages:128-131
AbstractA switch-on gene deletion detection platform is reported based on the alteration of the effective distance between G-quadruplex DNA and silver nanoclusters (AgNCs). Moreover, the role of the G- quadruplex structure in interacting with AgNCs has also been demonstrated. The detection of the deletion mutants of LMP1 and CCR5 genes is performed as the proof-of-concept of our assay. Finally, the potential biological application of the assay was demonstrated in 10% v/v human serum.
DOI10.1039/c6qm00068a
Indexed BySCI
Language英语
WOS Research AreaChemistry ; Materials Science
WOS SubjectChemistry, Multidisciplinary ; Materials Science, Multidisciplinary
WOS IDWOS:000412438100012
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Cited Times [WOS]:5   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorMa, DL
Affiliation1.Hong Kong Baptist Univ, Dept Chem, Kowloon Tong, Hong Kong, Peoples R China
2.University of Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Macau, Peoples R China
Recommended Citation
GB/T 7714
Wang, MD,Wang, WH,Liu, CF,et al. A luminescence switch-on assay for the detection of specific gene deletion using G-quadruplex DNA and silver nanoclusters[J]. MATERIALS CHEMISTRY FRONTIERS,2017,1(1):128-131.
APA Wang, MD.,Wang, WH.,Liu, CF.,Liu, JB.,Kang, TS.,...&Ma, DL.(2017).A luminescence switch-on assay for the detection of specific gene deletion using G-quadruplex DNA and silver nanoclusters.MATERIALS CHEMISTRY FRONTIERS,1(1),128-131.
MLA Wang, MD,et al."A luminescence switch-on assay for the detection of specific gene deletion using G-quadruplex DNA and silver nanoclusters".MATERIALS CHEMISTRY FRONTIERS 1.1(2017):128-131.
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