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Iridium(III) complexes with 1,10-phenanthrolinebased N^N ligands as highly selective luminescent G-quadruplex probes and application for switch-on ribonuclease H detection
Lu, LH1,2; Wang, WH2; Yang, C3; Kang, TS3; Leung, CH3; Ma, DL2
2016
Source PublicationJOURNAL OF MATERIALS CHEMISTRY B
ISSN2050-750X
Volume4Issue:42Pages:6791-6796
Abstract

A systematic study was performed to investigate the relationship between molecular structure and G-quadruplex sensing ability for a series of structurally related cyclometallated iridium(III) complexes. The novel complex 7 was used to construct a label-free luminescent switch-on G-quadruplex-based assay for RNase H activity in buffered solution. The constructed detection platform was simple, low-cost and highly sensitive for RNase H, and functioned effectively in the presence of cellular debris.

DOI10.1039/c6tb02316a
Indexed BySCI
Language英语
WOS Research AreaMaterials Science
WOS SubjectMaterials Science, bioMaterials
WOS IDWOS:000387225800004
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Cited Times [WOS]:25   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorLu, LH; Leung, CH; Ma, DL
Affiliation1.Qingdao Agr Univ, Coll Chem & Pharmaceut Sci, Qingdao 266109, Peoples R China
2.Hong Kong Baptist Univ, Dept Chem, Kowloon Tong, Hong Kong, Peoples R China
3.University of Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Macau, Peoples R China
Corresponding Author AffilicationUniversity of Macau
Recommended Citation
GB/T 7714
Lu, LH,Wang, WH,Yang, C,et al. Iridium(III) complexes with 1,10-phenanthrolinebased N^N ligands as highly selective luminescent G-quadruplex probes and application for switch-on ribonuclease H detection[J]. JOURNAL OF MATERIALS CHEMISTRY B,2016,4(42):6791-6796.
APA Lu, LH,Wang, WH,Yang, C,Kang, TS,Leung, CH,&Ma, DL.(2016).Iridium(III) complexes with 1,10-phenanthrolinebased N^N ligands as highly selective luminescent G-quadruplex probes and application for switch-on ribonuclease H detection.JOURNAL OF MATERIALS CHEMISTRY B,4(42),6791-6796.
MLA Lu, LH,et al."Iridium(III) complexes with 1,10-phenanthrolinebased N^N ligands as highly selective luminescent G-quadruplex probes and application for switch-on ribonuclease H detection".JOURNAL OF MATERIALS CHEMISTRY B 4.42(2016):6791-6796.
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