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A novel dual sensitive polymer-gambogic acid conjugate: synthesis, characterization, and in vitro evaluation
Ke Song1; Zhaobo Wang1; Xue Liu2; Guolin Zhang2; Xin Wang1; DeFang Ouyang3; Mingrui Guo1; Lijiang Chen1,4
2019-09-26
Source PublicationNANOTECHNOLOGY
ISSN0957-4484
Volume30Issue:50
Abstract

Currently, bio-simulate drug delivery systems are highly considered for efficient targeting of tumors. Nevertheless, there are some potential problems such as intelligent release efficiency, subsequently, influence cell toxicity and blood circulation stability. A novel type of stimuliresponsive nanoparticle was developed in accordance with the specific tumor microenvironment to deliver gambogic acid (GA). Herein, we successfully connected GA with mPEG via two different sensitive linkages, valine-citrulline (VC) and cystamine. The structure was characterized by ESI-MS, 1H NMR, FT-IR or MALDI-TOF-MS. The mPEG-VC-SS-GA-NPs (PVSG-NPs) were rapidly prepared. The properties of nanoparticles, including solubility, particle size, morphology, and sensitive drug release performance, were investigated. Compared to single sensitive conjugate (mPEG-SS-GA-NPs, PSG-NPs), PVSG-NPs demonstrated greater solubility and higher sensitive release profile. Cytotoxicity test indicated that PVSG-NPs had apparent cytotoxicity on HepG2 cells and reduced cytotoxicity on normal cells. Additionally, PVSG-NPs mainly kill HepG2 cells by inducing early and late apoptosis and restraining the G0/G1 phase proliferation. Albumin adsorption test revealed that the PVSG-NPs had little albumin combination, consequently, enhancing their circulation constancy. In summary, our findings suggested the novel PVSG-NPs capable of being used for tumor targeting and further practical applications.
 

KeywordPolymer-drug Conjugate Gambogic Acid Sensitive Drug Delivery Cathepsin b Glutathione
DOI10.1088/1361-6528/ab40ee
Indexed BySCI
Language英语
WOS Research AreaScience & Technology - Other Topics ; Materials Science ; Physics
WOS SubjectNanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
WOS IDWOS:000488090300001
PublisherOP PUBLISHING LTD, TEMPLE CIRCUS, TEMPLE WAY, BRISTOL BS1 6BE, ENGLAND
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Cited Times [WOS]:3   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorLijiang Chen
Affiliation1.School of Pharmaceutical Science, Liaoning University, Shenyang, 110036, People’s Republic of China
2.College of Chemistry, Liaoning University, Shenyang, 110036, People’s Republic of China
3.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences (ICMS), University of Macau, Macau, People’s Republic of China
4.Liaoning Key Laboratory of New Drug Research & Development, Shenyang, 110036, People’s Republic of China
Recommended Citation
GB/T 7714
Ke Song,Zhaobo Wang,Xue Liu,et al. A novel dual sensitive polymer-gambogic acid conjugate: synthesis, characterization, and in vitro evaluation[J]. NANOTECHNOLOGY,2019,30(50).
APA Ke Song.,Zhaobo Wang.,Xue Liu.,Guolin Zhang.,Xin Wang.,...&Lijiang Chen.(2019).A novel dual sensitive polymer-gambogic acid conjugate: synthesis, characterization, and in vitro evaluation.NANOTECHNOLOGY,30(50).
MLA Ke Song,et al."A novel dual sensitive polymer-gambogic acid conjugate: synthesis, characterization, and in vitro evaluation".NANOTECHNOLOGY 30.50(2019).
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