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Deciphering the metabolic role of AMPK in cancer multi-drug resistance
Wen Tan1,2; Zhangfeng Zhong3,4; Randy P. Carney5; Yongfan Men2; Jiannan Li2; Tingrui Pan2; Yitao Wang4
2018-09-24
Source PublicationSEMINARS IN CANCER BIOLOGY
ISSN1044-579X
Volume56Pages:56-71
Abstract

Multi-drug resistance (MDR) is a curious bottleneck in cancer research and chemotherapy, whereby some cells rapidly adapt to the tumor microenvironment via a myriad of heterogeneous metabolic activities. Despite being a major impediment to treatment, there is a silver lining: control over metabolic regulation could be an effective approach to overcome or correct resistance pathways. In this critical review, we comprehensively and carefully curated and analyzed large networks of previously identified proteins associated with metabolic adaptation in MDR. We employed data and text mining to study and categorize more than 600 studies in PubMed, with particular focus on AMPK, a central and fundamental modulator in the energy metabolism network that has been specifically implicated in cancer MDR pathways. We have identified one protein set of metabolic adaptations with 137 members closely related to cancer MDR processes, and a second protein set with 165 members derived from AMPK-based networks, with 28 proteins found at the intersection between the two sets. Furthermore, according to genomics analysis of the cancer genome atlas (TCGA) provisional data, the highest alteration frequency (80.0%) of the genes encoding the intersected proteins (28 proteins), ranked three cancer types with quite remarkable significance across 166 studies. The hierarchical relationships of the entire identified gene and protein networks indicate broad correlations in AMPK-mediated metabolic regulation pathways, which we use decipher and depict the metabolic roles of AMPK and demonstrate the potential of metabolic control for therapeutic intervention in MDR.

KeywordAmpk Metabolic Reprogramming Multi-drug Resistance Cancer
DOI10.1016/j.semcancer.2018.09.005
Indexed BySCI
Language英语
WOS Research AreaOncology
WOS SubjectOncology
WOS IDWOS:000471356500007
PublisherACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
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Cited Times [WOS]:7   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorTingrui Pan; Yitao Wang
Affiliation1.School of Pharmacy, Lanzhou University, Lanzhou, Gansu province 730000, China
2.Micro-Nano Innovations (MiNI) Laboratory, Biomedical Engineering, University of California, Davis, CA 95616, United States
3.Center for Developmental Therapeutics, Chemistry of Life Processes Institute, Northwestern University, Evanston, IL 60202, United States
4.Institute of Chinese Medical Sciences, State Key Laboratory of Quality Research in Chinese Medicine, University of Macau, Macau SAR, 999078, China
5.Department of Biomedical Engineering, University of California Davis, Davis, CA 95616, United States
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Wen Tan,Zhangfeng Zhong,Randy P. Carney,et al. Deciphering the metabolic role of AMPK in cancer multi-drug resistance[J]. SEMINARS IN CANCER BIOLOGY,2018,56:56-71.
APA Wen Tan.,Zhangfeng Zhong.,Randy P. Carney.,Yongfan Men.,Jiannan Li.,...&Yitao Wang.(2018).Deciphering the metabolic role of AMPK in cancer multi-drug resistance.SEMINARS IN CANCER BIOLOGY,56,56-71.
MLA Wen Tan,et al."Deciphering the metabolic role of AMPK in cancer multi-drug resistance".SEMINARS IN CANCER BIOLOGY 56(2018):56-71.
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