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Identification of an Iridium(III)-Based Inhibitor of Tumor Necrosis Factor-alpha
Kang TS1; Mao Z2; Ng CT1; Wang M2; Wang W2; Wang C1; Lee SM1; Wang Y1; Leung CH1; Ma DL2
2016
Source PublicationJOURNAL OF MEDICINAL CHEMISTRY
ISSN0022-2623
Volume59Issue:8Pages:4026-4031
AbstractThe novel iridium(III) complex 1 was verified as a potent inhibitor of the TNF-α-TNFR protein-protein interaction in vitro and in cellulo. The iridium(III) center plays a critical role in organizing the structure of the bioactive metal complex, as the isolated ligands were found to be completely inactive. Both iridium enantiomers inhibited TNF-α-induced NF-κB activity and TNF-α-TNFR binding. 1 represents a promising scaffold for the further development of more potent organometallic TNF-α inhibitors.
DOI10.1021/acs.jmedchem.6b00112
Indexed BySCI
Language英语
WOS Research AreaPharmacology & Pharmacy
WOS SubjectChemistry, Medicinal
WOS IDWOS:000375519900031
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Cited Times [WOS]:34   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau , Taipa, Macao, P. R. China.
2.Department of Chemistry, Hong Kong Baptist University , Kowloon Tong, Hong Kong, P. R. China.
First Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Kang TS,Mao Z,Ng CT,et al. Identification of an Iridium(III)-Based Inhibitor of Tumor Necrosis Factor-alpha[J]. JOURNAL OF MEDICINAL CHEMISTRY,2016,59(8):4026-4031.
APA Kang TS.,Mao Z.,Ng CT.,Wang M.,Wang W.,...&Ma DL.(2016).Identification of an Iridium(III)-Based Inhibitor of Tumor Necrosis Factor-alpha.JOURNAL OF MEDICINAL CHEMISTRY,59(8),4026-4031.
MLA Kang TS,et al."Identification of an Iridium(III)-Based Inhibitor of Tumor Necrosis Factor-alpha".JOURNAL OF MEDICINAL CHEMISTRY 59.8(2016):4026-4031.
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