UM  > 中藥質量研究國家重點實驗室(澳門大學)
Effect of Resveratrol on differentiation of cardiomyoblast
Leong CW1; Wong CH2; Lao SC1; Leong EC1; Lao IF1; Law PT2; Fung KP2,3; Tsang KS4; Waye MM2; Tsui SK2; Wang YT1; Lee SM1,3
2006
Source PublicationACTA PHARMACOLOGICA SINICA
ISSN1671-4083
Volume27Issue:329-330
Abstract

Resveratrol (trans-3,5,4'-trihydroxystilbene), a polyphenolic compound found largely in the skins of red grapes, has been used as a nutritional supplement or an investigational new drug for prevention of cardiovascular diseases. Previous reports showed that resveratrol had a protective effect against oxidative agent-induced cell injury. Our studies indicate that resveratrol plays a role in the differentiation of cardiomyoblasts. The cardiomyoblast cell line, H9c2, was exposed to 30-120 microM resveratrol for up to 5 days. Resveratrol inhibits cardiomyoblast proliferation without causing cells injury. Moreover, resveratrol treatment modulated the differentiation of morphological characteristics including elongation and cell fusion in cardiomyoblasts. Proliferation and differentiation of H9c2 cells were further revealed by measurement of the mRNA expression of a cell cycle marker (CDK2), a differentiation marker (myogenin), and a contractile apparatus protein (MLC-2). Gene expression analysis revealed that resveratrol promoted entry into cell cycle arrest but extended the myogenic differentiation progress. These results have implications for the role of resveratrol in modulating cell cycle control and differentiation in cardiomyoblasts.

KeywordResveratrol Differentiation Cardiomyoblast
DOI10.1016/j.bbrc.2007.06.025
Indexed BySCI
Language英语
WOS Research AreaChemistry ; Pharmacology & Pharmacy
WOS SubjectChemistry, Multidisciplinary ; Pharmacology & Pharmacy
WOS IDWOS:000239590002600
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Cited Times [WOS]:0   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionTHE STATE KEY LABORATORY OF QUALITY RESEARCH IN CHINESE MEDICINE (UNIVERSITY OF MACAU)
Institute of Chinese Medical Sciences
Corresponding AuthorWang YT; Lee SM
Affiliation1.Institute of Chinese Medical Sciences, University of Macau, Taipa, Macao, China
2.Department of Biochemistry, The Chinese University of Hong Kong, Hong Kong, China
3.Institute of Chinese Medicine, The Chinese University of Hong Kong, Hong Kong, China
4.Department of Anatomical & Cellular Pathology, The Chinese University of Hong Kong, Hong Kong, China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Leong CW,Wong CH,Lao SC,et al. Effect of Resveratrol on differentiation of cardiomyoblast[J]. ACTA PHARMACOLOGICA SINICA,2006,27(329-330).
APA Leong CW.,Wong CH.,Lao SC.,Leong EC.,Lao IF.,...&Lee SM.(2006).Effect of Resveratrol on differentiation of cardiomyoblast.ACTA PHARMACOLOGICA SINICA,27(329-330).
MLA Leong CW,et al."Effect of Resveratrol on differentiation of cardiomyoblast".ACTA PHARMACOLOGICA SINICA 27.329-330(2006).
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