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Gene delivery based on macrocyclic amphiphiles
Wen-Chao Geng1; Qiaoxian Huang2; Zhe Xu1; Ruibing Wang2; Dong-Sheng Guo1
2019
Source PublicationTHERANOSTICS
ISSN1838-7640
Volume9Issue:11Pages:3094-3106
Abstract

Gene therapy, with an important role in biomedicine, often requires vectors for gene condensation in order to avoid degradation, improve membrane permeation, and achieve targeted delivery. Macrocyclic molecules are a family of artificial receptors that can selectively bind a variety of guest species. Amphiphilic macrocycles, particularly those bearing cationic charges and their various assemblies represent a new class of promising non-viral vectors with intrinsic advantages in gene condensation and delivery. The most prominent examples include amphiphilic cyclodextrins, calixarenes and pillararenes. Herein, we systemically reviewed reported assemblies of amphiphilic macrocycles for gene delivery and therapy. The advantages and disadvantages of each type of macrocyclic amphiphiles for gene delivery, as well as the perspectives on the future development of this area are discussed.

KeywordMacrocyclic Amphiphiles Gene Delivery
DOI10.7150/thno.31914
Indexed BySCI
Language英语
WOS Research AreaResearch & Experimental Medicine
WOS SubjectMedicine, Research & Experimental
WOS IDWOS:000468203100004
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Cited Times [WOS]:8   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorRuibing Wang
Affiliation1.College of Chemistry, Key Laboratory of Functional Polymer Materials (Ministry of Education), State Key Laboratory of Elemento-Organic Chemistry,Nankai University, Tianjin 300071, China
2.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macau SAR, China
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Wen-Chao Geng,Qiaoxian Huang,Zhe Xu,et al. Gene delivery based on macrocyclic amphiphiles[J]. THERANOSTICS,2019,9(11):3094-3106.
APA Wen-Chao Geng,Qiaoxian Huang,Zhe Xu,Ruibing Wang,&Dong-Sheng Guo.(2019).Gene delivery based on macrocyclic amphiphiles.THERANOSTICS,9(11),3094-3106.
MLA Wen-Chao Geng,et al."Gene delivery based on macrocyclic amphiphiles".THERANOSTICS 9.11(2019):3094-3106.
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