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Using induced pluripotent stem cells for modeling Parkinson’s disease
Minjing Ke; Cheong-Meng Chong; Huanxing Su
2019-09
Source PublicationWORLD JOURNAL OF STEM CELLS
ISSN1948-0210
Volume11Issue:9Pages:634-649
Abstract

Parkinson’s disease (PD) is an age-related neurodegenerative disease caused by the progressive loss of dopaminergic (DA) neurons in the substantia nigra. As DA neurons degenerate, PD patients gradually lose their ability of movement. To date no effective therapies are available for the treatment of PD and its pathogenesis remains unknown. Experimental models that appropriately mimic the development of PD are certainly needed for gaining mechanistic insights into PD pathogenesis and identifying new therapeutic targets. Human induced pluripotent stem cells (iPSCs) could provide a promising model for fundamental research and drug screening. In this review, we summarize various iPSCs-based PD models either derived from PD patients through reprogramming technology or established by gene-editing technology, and the promising application of iPSC-based PD models for mechanistic studies and drug testing.

KeywordParkinson’s Disease Dopaminergic Neurons Induced Pluripotent Stem Cells Somatic Cell Reprogramming Aging
DOI10.4252/wjsc.v11.i9.634
Indexed BySCI
Language英语
WOS Research AreaCell Biology
WOS SubjectCell & Tissue Engineering ; Cell Biology
WOS IDWOS:000487846900006
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Cited Times [WOS]:2   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorHuanxing Su
AffiliationState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao 999078, China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Minjing Ke,Cheong-Meng Chong,Huanxing Su. Using induced pluripotent stem cells for modeling Parkinson’s disease[J]. WORLD JOURNAL OF STEM CELLS,2019,11(9):634-649.
APA Minjing Ke,Cheong-Meng Chong,&Huanxing Su.(2019).Using induced pluripotent stem cells for modeling Parkinson’s disease.WORLD JOURNAL OF STEM CELLS,11(9),634-649.
MLA Minjing Ke,et al."Using induced pluripotent stem cells for modeling Parkinson’s disease".WORLD JOURNAL OF STEM CELLS 11.9(2019):634-649.
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