UM  > 中華醫藥研究院
From Omics to Drug Metabolism and High Content Screen of Natural Product in Zebrafish: A New Model for Discovery of Neuroactive Compound
Ming Wai Hung1,2; Zai Jun Zhang1,2; Shang Li1,2; Benson Lei2; Shuai Yuan1,2; Guo Zhen Cui1,2; Pui Man Hoi1,2; Kelvin Chan3,4; Simon Ming Yuen Lee1,2
2012
Source PublicationEVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
ISSN1741-427X
Abstract

The zebrafish (Danio rerio) has recently become a common model in the fields of genetics, environmental science, toxicology, and especially drug screening. Zebrafish has emerged as a biomedically relevant model for in vivo high content drug screening and the simultaneous determination of multiple efficacy parameters, including behaviour, selectivity, and toxicity in the content of the whole organism. A zebrafish behavioural assay has been demonstrated as a novel, rapid, and high-throughput approach to the discovery of neuroactive, psychoactive, and memory-modulating compounds. Recent studies found a functional similarity of drug metabolism systems in zebrafish and mammals, providing a clue with why some compounds are active in zebrafish in vivo but not in vitro, as well as providing grounds for the rationales supporting the use of a zebrafish screen to identify prodrugs. Here, we discuss the advantages of the zebrafish model for evaluating drug metabolism and the mode of pharmacological action with the emerging omics approaches. Why this model is suitable for identifying lead compounds from natural products for therapy of disorders with multifactorial etiopathogenesis and imbalance of angiogenesis, such as Parkinson’s disease, epilepsy, cardiotoxicity, cerebral hemorrhage, dyslipidemia, and hyperlipidemia, is addressed.

DOI10.1155/2012/605303
Indexed BySCI
Language英语
WOS Research AreaIntegrative & Complementary Medicine
WOS SubjectIntegrative & Complementary Medicine
WOS IDWOS:000308291800001
Fulltext Access
Citation statistics
Cited Times [WOS]:30   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, University of Macau, Avenue Padre Tomas Pereira S.J., ´ Taipa, Macau, China
2.Institute of Chinese Medical Sciences, University of Macau, Avenue Padre Tomas Pereira S.J., Taipa, Macau, China
3.Faculty of Pharmacy, The University of Sydney, NSW 2006, Australia
4.Centre for Complementary Medicine Research, University of Western Sydney, NSW 2560, Australia
First Author AffilicationUniversity of Macau;  Institute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Ming Wai Hung,Zai Jun Zhang,Shang Li,et al. From Omics to Drug Metabolism and High Content Screen of Natural Product in Zebrafish: A New Model for Discovery of Neuroactive Compound[J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2012.
APA Ming Wai Hung.,Zai Jun Zhang.,Shang Li.,Benson Lei.,Shuai Yuan.,...&Simon Ming Yuen Lee.(2012).From Omics to Drug Metabolism and High Content Screen of Natural Product in Zebrafish: A New Model for Discovery of Neuroactive Compound.EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE.
MLA Ming Wai Hung,et al."From Omics to Drug Metabolism and High Content Screen of Natural Product in Zebrafish: A New Model for Discovery of Neuroactive Compound".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2012).
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Ming Wai Hung]'s Articles
[Zai Jun Zhang]'s Articles
[Shang Li]'s Articles
Baidu academic
Similar articles in Baidu academic
[Ming Wai Hung]'s Articles
[Zai Jun Zhang]'s Articles
[Shang Li]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Ming Wai Hung]'s Articles
[Zai Jun Zhang]'s Articles
[Shang Li]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.