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Lithium Enhances Axonal Regeneration in Peripheral Nerve by Inhibiting Glycogen Synthase Kinase 3β Activation
Huanxing Su1; Qiuju Yuan2; Dajiang Qin2; Xiaoying Yang2; Wai-Man Wong2; Kwok-Fai So2,3; Wutian Wu2,3
2014
Source PublicationBIOMED RESEARCH INTERNATIONAL
ISSN2314-6141
Abstract

Brachial plexus injury often involves traumatic root avulsion resulting in permanent paralysis of the innervated muscles. The lack of sufficient regeneration from spinal motoneurons to the peripheral nerve (PN) is considered to be one of the major causes of the unsatisfactory outcome of various surgical interventions for repair of the devastating injury. The present study was undertaken to investigate potential inhibitory signals which influence axonal regeneration after root avulsion injury. The results of the study showed that root avulsion triggered GSK-3β activation in the injured motoneurons and remaining axons in the ventral funiculus. Systemic application of a clinical dose of lithium suppressed activated GSK-3β in the lesioned spinal cord to the normal level and induced extensive axonal regeneration into replanted ventral roots. Our study suggests that GSK-3β activity is involved in negative regulation for axonal elongation and regeneration and lithium, the specific GSK-3β inhibitor, enhances motoneuron regeneration from CNS to PNS.

DOI10.1155/2014/658753
Indexed BySCI
Language英语
WOS Research AreaBiotechnology & Applied Microbiology ; Research & Experimental Medicine
WOS SubjectBiotechnology & Applied Microbiology ; Medicine, Research & Experimental
WOS IDWOS:000336570000001
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Cited Times [WOS]:7   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau
2.Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong
3.GHM Institute of CNS Regeneration, Jinan University, Guangzhou 510632, China
First Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Huanxing Su,Qiuju Yuan,Dajiang Qin,et al. Lithium Enhances Axonal Regeneration in Peripheral Nerve by Inhibiting Glycogen Synthase Kinase 3β Activation[J]. BIOMED RESEARCH INTERNATIONAL,2014.
APA Huanxing Su.,Qiuju Yuan.,Dajiang Qin.,Xiaoying Yang.,Wai-Man Wong.,...&Wutian Wu.(2014).Lithium Enhances Axonal Regeneration in Peripheral Nerve by Inhibiting Glycogen Synthase Kinase 3β Activation.BIOMED RESEARCH INTERNATIONAL.
MLA Huanxing Su,et al."Lithium Enhances Axonal Regeneration in Peripheral Nerve by Inhibiting Glycogen Synthase Kinase 3β Activation".BIOMED RESEARCH INTERNATIONAL (2014).
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