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n-3 Polyunsaturated fatty acids for the management of alcoholic liverdisease: A critical review
Meng Wang1,2; Li-Juan Ma1; Yan Yang3; Zeyu Xia4; jian-Bo Wan1
2019-07
Conference Name3rd International Symposium on Phytochemicals in Medicine and Food (ISPMF)
Source PublicationCRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
Conference Date2018-8
Conference PlaceKunming, PEOPLES R CHINA
Abstract

Excess alcohol exposure leads to alcoholic liver disease (ALD), a predominant cause of liver-related morbidity and mortality worldwide. In the past decade, increasing attention has been paid to understand the association between n-3 polyunsaturated fatty acids (n-3 PUFAs) and ALD. In this review, we summarize the metabolism of n-3 PUFAs, animal model of ALD, and the findings from recent studies determining the role of n-3 PUFAs in ALD as a possible treatment. The animal models of acute ethanol exposure, chronic ethanol exposure and chronic-plus-single binge ethanol feeding have been widely used to explore the impact of n-3 PUFAs. Although the results of studies regarding the role of n-3 PUFAs in ALD have been inconsistent or controversial, increasing evidence has demonstrated that n-3 PUFAs may be useful in alleviating alcoholic steatosis and alcohol-induced liver injury through multiple mechanisms, including decreased de novo lipogenesis and lipid mobilization from adipose tissue, enhanced mitochondrial fatty acid β-oxidation, reduced hepatic inflammation and oxidative stress, and promoted intestinal homeostasis, positively suggesting that n-3 PUFAs might be promising for the management of ALD. The oxidation of n-3 PUFAs ex vivo in an experimental diet was rarely considered in most n-3 PUFA-related studies, likely contributing to the inconsistent results. Thus, the role of n-3 PUFAs in ALD deserves greater research efforts and remains to be evaluated in randomized, placebo-controlled clinic trial.

KeywordAlcoholic Liver Disease Alcoholic Steatosis Intestinal Homeostasis Inflammation N-3 Polyunsaturated Fatty Acids Oxidative Stress
DOI10.1080/10408398.2018.1544542
Indexed BySCI
Language英语
WOS Research AreaFood Science & Technology ; Nutrition & Dietetics
WOS SubjectFood Science & Technology ; Nutrition & Dietetics
WOS IDWOS:000470673800009
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Cited Times [WOS]:7   [WOS Record]     [Related Records in WOS]
Document TypeConference paper
CollectionInstitute of Chinese Medical Sciences
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao,China
2.Collaborative Translational Medicine CollaborativeInnovation Center, Department of Pharmacology and Chemical Biology, Institute of Medical Sciences, Shanghai Jiao Tong University Schoolof Medicine, Shanghai, China
3.Center for Drug Innovation and Discovery, College of Life Science, Hebei Normal University, Shijiazhuang, Hebei, China
4.Departmentof Nutrition, School of Public Health, Sun Yat-Sen University, Guangzhou, China
First Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Meng Wang,Li-Juan Ma,Yan Yang,et al. n-3 Polyunsaturated fatty acids for the management of alcoholic liverdisease: A critical review[C],2019.
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