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Regulation of glucose metabolism by bioactive phytochemicals for the management of type 2 diabetes mellitus
Chao Zhao1,2; Chengfeng Yang1,3; Sydney Tang Chi Wai4; Yanbo Zhang5; Maria P. Portillo6,7; Paolo Paoli8; Yijing Wu2,9; Wai San Cheang10; Bin Liu1; Christian Carpéné11; Jianbo Xiao10; Hui Cao1,10
2019-03
Conference Name3rd International Symposium on Phytochemicals in Medicine and Food (ISPMF)
Source PublicationCRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
Volume59
Issue6
Pages830-847
Conference Date2018-8
Conference PlaceKunming, PEOPLES R CHINA
Abstract

Type 2 diabetes mellitus (T2DM) is the most prevalent disease and becoming a serious public health threat worldwide. It is a severe endocrine metabolic disorder that has the ability to induce serious complications in all kinds of organs. Although mechanisms of anti-diabetics have been described before, we focus here on the cellular and physiological mechanisms involved in the modulation of insulin and glucose blood levels. As obesity and inflammation are intimately associated with the development of T2DM, their possible relationships are also described. The effects of gut microbiota on insulin resistance have been recently investigated in clinical trials, and we discuss the potential mechanisms by which gut microbiota may improve glucose handling, especially via the metabolism of ingested phytochemicals. Among the historically supported effects of phytochemicals, their therapeutic potential for T2DM leads to consider these natural products as an important pool for the identification of novel anti-diabetic drug leads. This current research extends the descriptions of anti-diabetic effects of plants that are used in traditional medicines or as nutraceuticals. The objective of the present review is to make a systematic report on glucose metabolism in T2DM as well as to explore the relationships between natural phytochemicals and glucose handling.

KeywordType 2 Diabetes Metabolic Pathways Gut Microbiota Phytochemicals New Therapies
DOI10.1080/10408398.2018.1501658
Indexed BySCI
Language英语
WOS Research AreaFood Science & Technology ; Nutrition & Dietetics
WOS SubjectFood Science & Technology ; Nutrition & Dietetics
WOS IDWOS:000467738800002
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Cited Times [WOS]:26   [WOS Record]     [Related Records in WOS]
Document TypeConference paper
CollectionInstitute of Chinese Medical Sciences
Affiliation1.College of Food Science, Fujian Agriculture and Forestry University, Fuzhou, China
2.Department of Chemistry, University of California,Davis, CA, USA
3.Institute of Oceanography, Minjiang University, Fuzhou, China
4.Department of Medicine, LKS Faculty of Medicine, TheUniversity of Hong Kong, Queen Mary Hospital, Hong Kong
5.School Chinese Medicine, University of Hong Kong, Hong Kong, China
6.Department of Nutrition and Food Science, Faculty of Pharmacy, University of Basque Country (UPV/EHU) and Lucio Lascaray ResearchCenter, Vitoria, Spain
7.CIBEROBN Physiopathology of Obesity and Nutrition, Institute of Health Carlos III (ISCIII), Spain
8.Department of Biomedical, Experimental and Clinical Sciences, University of Florence, Florence, Italy
9.College of Food Science and Nutritional Engineering,China Agricultural University, China
10.nstitute of Chinese Medical Sciences, State Key Laboratory of Quality Control in Chinese Medicine,University of Macau, Macau SAR, China
11.Institut des Maladies Metaboliques et Cardiovasculaires (I2MC), Institut National de la Santeetdela Recherche Medicale (INSERM U1048)/Universite Paul Sabatier, B^at. L4, CHU Rangueil, Toulouse cedex 4, France
Recommended Citation
GB/T 7714
Chao Zhao,Chengfeng Yang,Sydney Tang Chi Wai,et al. Regulation of glucose metabolism by bioactive phytochemicals for the management of type 2 diabetes mellitus[C],2019:830-847.
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