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dentification of an Iridium(III)-Based Inhibitor of Tumor Necrosis Factor‑α
Tian-Shu Kang1; Zhifeng Mao2; Chan-Tat Ng1; Modi Wang2; Wanhe Wang2; Chunming Wang1; Simon Ming-Yuen Lee1; Yitao Wang1; Chung-Hang Leung1; Dik-Lung Ma2
2016-04
Source PublicationJOURNAL OF MEDICINAL CHEMISTRY
ISSN0022-2623
Volume59Issue:8Pages:4026-4031
Abstract

The novel iridium(III) complex1was verified as a potentinhibitor of the TNF-α−TNFR protein−protein interaction in vitro and incellulo. The iridium(III) center plays a critical role in organizing thestructure of the bioactive metal complex, as the isolated ligands were foundto be completely inactive. Both iridium enantiomers inhibited TNF-α-induced NF-κB activity and TNF-α−TNFR binding.1represents apromising scaffold for the further development of more potentorganometallic TNF-αinhibitors.

DOI10.1021/acs.jmedchem.6b00112
Indexed BySCI
Language英语
WOS Research AreaPharmacology & Pharmacy
WOS SubjectChemistry, Medicinal
WOS IDWOS:000375519900031
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Cited Times [WOS]:34   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorChung-Hang Leung
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa,Macao, P. R. China
2.Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong, P. R. China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Tian-Shu Kang,Zhifeng Mao,Chan-Tat Ng,et al. dentification of an Iridium(III)-Based Inhibitor of Tumor Necrosis Factor‑α[J]. JOURNAL OF MEDICINAL CHEMISTRY,2016,59(8):4026-4031.
APA Tian-Shu Kang.,Zhifeng Mao.,Chan-Tat Ng.,Modi Wang.,Wanhe Wang.,...&Dik-Lung Ma.(2016).dentification of an Iridium(III)-Based Inhibitor of Tumor Necrosis Factor‑α.JOURNAL OF MEDICINAL CHEMISTRY,59(8),4026-4031.
MLA Tian-Shu Kang,et al."dentification of an Iridium(III)-Based Inhibitor of Tumor Necrosis Factor‑α".JOURNAL OF MEDICINAL CHEMISTRY 59.8(2016):4026-4031.
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