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2-甲氧基-6-乙酰基-7-甲基胡桃醌在制备治疗肿瘤疾病的药物中的应用
王一涛; 陈修平; 张庆文; 鲍娇琳
2013-03-27
Rights Holder澳門大學
Date Available2013-03-27
Country中國
Subtype发明专利
Contribution Rank1
Abstract

本发明公开了2-甲氧基-6-乙酰基-7-甲基胡桃醌在制备治疗肿瘤疾病的药物中的应用。本发明在对MAM的抗肿瘤活性的研究中发现,MAM在体外对所测定的多种肿瘤细胞的增殖具有显著的抑制活性,显示出较好的细胞毒性作用,其IC50均小于或等于10μM,并且具有良好的量效关系,同时将其作用于正常肝细胞株LO2,其细胞毒性低于其对肝肿瘤细胞HepG2的毒性反应,此外,还发现MAM可明显降低肿瘤细胞线粒体膜电位,诱导细胞凋亡。

Application Date2012-11-20
Patent NumberCN102988334A
Language中文
Status已授权
Application NumberCN201210472784.9
Open (Notice) NumberCN102988334A
Patent Agent周瑞儀
Agency廣州新諾專利商標事務所有限公司
Fulltext Access
Document TypePatent
CollectionInstitute of Chinese Medical Sciences
Affiliation澳門大學
First Author AffilicationUniversity of Macau
Recommended Citation
GB/T 7714
王一涛,陈修平,张庆文,等. 2-甲氧基-6-乙酰基-7-甲基胡桃醌在制备治疗肿瘤疾病的药物中的应用. CN102988334A[P]. 2013-03-27.
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