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一类苄泽修饰壳聚糖嫁接物及其制备方法、 应用
余华; 王一涛; 熊炜
2019-03-19
Rights Holder澳门大学
Date Available2019-03-19
Country中国
Subtype发明专利
Contribution Rank1
Abstract

本发明提供苄泽修饰壳聚糖嫁接物,通过两 步反应以丁二酸将苄泽末端羟基与壳聚糖中氨 基发生化学键合,生成苄泽修饰壳聚糖嫁接物。 苄泽修饰壳聚糖嫁接物通过自聚集方法和静电 吸引与负电性多聚磷酸钠复合形成纳米递释系 统。苄泽的修饰使得此嫁接物具有P糖蛋白外排 的抑制作用,提高小肠上皮细胞的摄取,以增加 药物的吸收,从而提高药物生物利用度提高疗 效。该纳米递送系统具有显著的抑制P糖蛋白底 物外排能力,可在口服药物中应用。

Application Date2018-09-04
Patent NumberCN109485748A
Language中文
Status已授权
Application NumberCN201811024505.6
Open (Notice) NumberCN109485748A
Patent Agent王斌
Agency北京德崇智捷知识产权代理 有限公司
Fulltext Access
Document TypePatent
CollectionInstitute of Chinese Medical Sciences
Affiliation澳門大學中華醫藥研究院
First Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
余华,王一涛,熊炜. 一类苄泽修饰壳聚糖嫁接物及其制备方法、 应用. CN109485748A[P]. 2019-03-19.
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