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Metabolites-Enabled Survival of Crucian Carps Infected by Edwardsiella tarda in High Water Temperature
Ming Jiang1,2; Zhuang-gui Chen3; Jun Zheng4; Bo Peng1,2,3,5
2019-08-22
Source PublicationFRONTIERS IN IMMUNOLOGY
ISSN1664-3224
Volume10
AbstractTemperature is one of the major factors that affect the outbreak of infectious disease. Lines of evidences have shown that virulence factors can be controlled by thermo-sensors in bacterial pathogens. However, how temperature influences host's responses to the pathogen is still largely unexplored, and the study of this might pave the way to develop strategies to manage pathogenic bacterial infection. In the present study, we show that finfish Carassius carassius, the crucian carp that is tolerant to a wide range of temperatures, is less susceptible to bacterial infection when grown in 20 degrees C than in 30 degrees C. The different responses of C. carassius to bacterial infection could be partially explained by the distinct metabolisms under the specific temperatures: C. carassius shows elevated tricarboxylic acid cycle (TCA cycle) but decreased taurine and hypotaurine metabolism as well as lower biosynthesis of unsaturated fatty acids at 30 degrees C. The decreased abundance of palmitate, threonine, and taurine represents the most characteristic metabolic feature. Consistently, exogenous palmitate, threonine, or taurine enhances the survival of C. carassius to bacterial infection at 30 degrees C in a dose-dependent manner. This effect could be attributed to the inhibition on the TCA cycle by the three metabolites. This notion is further supported by the fact that low concentration of malonate, a succinate dehydrogenase inhibitor, increases the survival of C. carassius at 30 degrees C as well. On the other hand, addition of the three metabolites rescued the decreased expression of pro-inflammatory cytokines including TNF-alpha 1, TNF-alpha 2, IL-1 beta 1, IL-1 beta 2, and lysozyme at 30 degrees C. Taken together, our results revealed an unexpected relationship between temperature and metabolism that orchestrates the immune regulation against infection by bacterial pathogens. Thus, this study shed light on the modulation of finfish physiology to fight against bacterial infection through metabolism.
KeywordWater Temperature Bacterial Infection Carassius Carassius Metabolome Innate Immunity
DOI10.3389/fimmu.2019.01991
Indexed BySCI
Language英语
WOS Research AreaImmunology
WOS SubjectImmunology
WOS IDWOS:000482194600001
PublisherFRONTIERS MEDIA SA, AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
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Cited Times [WOS]:5   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorBo Peng
Affiliation1.State Key Laboratory of Bio-Control, Higher Education Mega Center, School of Life Sciences, Sun Yat-sen University, Guangzhou, China
2.Department of Pediatrics, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
3.Faculty of Health Sciences, University of Macau, Macau, China
4.Southern Marine Science and Engineering Guangdong Laboratory, Zhuhai, China
5.Laboratory for Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Qingdao, China
Corresponding Author AffilicationFaculty of Health Sciences
Recommended Citation
GB/T 7714
Ming Jiang,Zhuang-gui Chen,Jun Zheng,et al. Metabolites-Enabled Survival of Crucian Carps Infected by Edwardsiella tarda in High Water Temperature[J]. FRONTIERS IN IMMUNOLOGY,2019,10.
APA Ming Jiang,Zhuang-gui Chen,Jun Zheng,&Bo Peng.(2019).Metabolites-Enabled Survival of Crucian Carps Infected by Edwardsiella tarda in High Water Temperature.FRONTIERS IN IMMUNOLOGY,10.
MLA Ming Jiang,et al."Metabolites-Enabled Survival of Crucian Carps Infected by Edwardsiella tarda in High Water Temperature".FRONTIERS IN IMMUNOLOGY 10(2019).
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