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Diagnostic extended usefulness of RMI: comparison of four risk of malignancy index in preoperative differentiation of borderline ovarian tumors and benign ovarian tumors
Shuang Zhang1; Shan Yu2,4; Wenying Hou5; Xiaoying Li1; Chunping Ning3; Yingnan Wu1; Feng Zhang1; Yu Fei Jiao4; Leo Tsz On Lee2; Litao Sun1
2019-09-16
Source PublicationJOURNAL OF OVARIAN RESEARCH
ISSN1757-2215
Volume12Issue:1
AbstractBackground This study aimed to examine the performance of the four risk of malignancy index (RMI) in discriminating borderline ovarian tumors (BOTs) and benign ovarian masses in daily clinical practice. Methods A total of 162 women with BOTs and 379 women with benign ovarian tumors diagnosed at the Second Affiliated Hospital of Harbin Medical University from January 2012 to December 2016 were enrolled in this retrospective study. Also, we classified these patients into serous borderline ovarian tumor (SBOT) and mucinous borderline ovarian tumor (MBOT) subgroup. Preoperative ultrasound findings, cancer antigen 125 (CA125) and menopausal status were reviewed. The area under the curve (AUC) of receiver operator characteristic curves (ROC) and performance indices of RMI I, RMI II, RMI III and RMI IV were calculated and compared for discrimination between benign ovarian tumors and BOTs. Results RMI I had the highest AUC (0.825, 95% CI: 0.790-0.856) among the four RMIs in BOTs group. Similar results were found in SBOT (0.839, 95% CI: 0.804-0.871) and MBOT (0.791, 95% CI: 0.749-0.829) subgroups. RMI I had the highest specificity among the BOTs group (87.6, 95% CI: 83.9-90.7%), SBOT (87.6, 95% CI: 83.9-90.7%) and MBOT group (87.6, 95% CI: 83.9-90.7%). RMI II scored the highest overall in terms of sensitivity among the BOTs group (69.75, 95% CI: 62.1-76.7%), SBOT (74.34, 95% CI: 65.3-82.1%) and MBOT (59.18, 95% CI: 44.2-73.0%) group. Conclusion Compared to other RMIs, RMI I was the best-performed method for differentiation of BOTs from benign ovarian tumors. At the same time, RMI I also performed best in the discrimination SBOT from benign ovarian tumors.
KeywordBorderline Ovarian Tumor Preoperative Evaluation Risk Of Malignancy Index Differential Diagnosis Benign Ovarian Tumor
DOI10.1186/s13048-019-0568-3
Indexed BySCI
Language英语
WOS Research AreaReproductive Biology
WOS SubjectReproductive Biology
WOS IDWOS:000486196200001
PublisherBMC, CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
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Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorLitao Sun
Affiliation1.Department of Ultrasound, The Secondary Affiliated Hospital of Harbin Medical University, Harbin, China
2.Centre of Reproduction Development and Aging, Faculty of Health Sciences, University of Macau, Macau SAR, China
3.Department of Ultrasound, The Affiliated Hospital of Qingdao University, Qingdao, China
4.Department of Pathology, The Secondary Affiliated Hospital of Harbin Medical University, Harbin, China
5.Department of Ultrasound, XuanWu Hospital of Capital Medical University, Beijing, China
Recommended Citation
GB/T 7714
Shuang Zhang,Shan Yu,Wenying Hou,et al. Diagnostic extended usefulness of RMI: comparison of four risk of malignancy index in preoperative differentiation of borderline ovarian tumors and benign ovarian tumors[J]. JOURNAL OF OVARIAN RESEARCH,2019,12(1).
APA Shuang Zhang.,Shan Yu.,Wenying Hou.,Xiaoying Li.,Chunping Ning.,...&Litao Sun.(2019).Diagnostic extended usefulness of RMI: comparison of four risk of malignancy index in preoperative differentiation of borderline ovarian tumors and benign ovarian tumors.JOURNAL OF OVARIAN RESEARCH,12(1).
MLA Shuang Zhang,et al."Diagnostic extended usefulness of RMI: comparison of four risk of malignancy index in preoperative differentiation of borderline ovarian tumors and benign ovarian tumors".JOURNAL OF OVARIAN RESEARCH 12.1(2019).
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