Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

doi:10.1016/0092-8674(95)90039-X

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	Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control
	Chuxia Deng1,2 ; Pumin Zhang 3; J.Wade Harper 3; Stephen J.Elledge 1,3,4; Philip Leder 1,2
	1995-08
Source Publication	CELL
ISSN	0092-8674
Volume	82 Issue:4 Pages:675-684
Abstract	p21CIP11WAF1 is a CDK Inhibitor regulated by the tumor suppressor p53 and is hypothesized to mediate G1 arrest. p53 has been suggested to derive anti-oncogenic properties from this relationship. To test these notions, we created mice lacking p21CIP1/WAF1. They develop normally and (unlike p53−/− mice) have not developed spontaneous malignancies during 7 months of observation. Nonetheless, p21−/− embryonic fibroblasts are significantly deficient in their ability to arrest in G1 In response to DNA damage and nucleotide pool perturbation. p21−/− cells also exhibit a significant growth alteration in vitro, achieving a saturation density as high as that observed In p53−/− cells. In contrast, other aspects of p53 function, such as thymocytic apoptosis and the mitotic spindle checkpoint, appear normal. These results establish the role of p21CIP1/WAF1 in the G1 checkpoint, but suggest that the antiapoptotic and the anti-oncogenic effects of p53 are more complex.
DOI	10.1016/0092-8674(95)90039-X
Indexed By	SCI
Language	英语
WOS Research Area	Biochemistry & Molecular Biology ; Cell Biology
WOS Subject	Biochemistry & Molecular Biology ; Cell Biology
WOS ID	WOS:A1995RR73400018
Fulltext Access	View Full-Text via DOI View Full-Text via Web of Science
Citation statistics	Cited Times [WOS]:1843 [WOS Record] [Related Records in WOS]
Document Type	Journal article
Collection	Personal research not belonging to the institution Faculty of Health Sciences
Affiliation	1.Howard Hughes Medical Institute Harvard Medical School Boston, Massachusetts 02115, USA 2.Department of Genetics Harvard Medical School Boston, Massachusetts 02115, USA 3.Vern and Marrs McLean Department of Biochemistry Baylor College of Medicine Houston, Texas 77030, USA 4.Department of Human and Molecular Genetics Baylor College of Medicine Houston, Texas 77030, USA
Recommended Citation GB/T 7714	Chuxia Deng,Pumin Zhang,J.Wade Harper,et al. Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control[J]. CELL,1995,82(4):675-684.
APA	Chuxia Deng,Pumin Zhang,J.Wade Harper,Stephen J.Elledge,&Philip Leder.(1995).Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control.CELL,82(4),675-684.
MLA	Chuxia Deng,et al."Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control".CELL 82.4(1995):675-684.

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