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Polymer Dots Compartmentalized in Liposomes as a Photocatalyst for In Situ Hydrogen Therapy
Boyu Zhang1,2; Fei Wang3; Hua Zhou1; Duyang Gao4; Zhen Yuan1; Changfeng Wu3; Xuanjun Zhang1
2019-02-25
Source PublicationANGEWANDTE CHEMIE-INTERNATIONAL EDITION
ISSN1433-7851
Volume58Issue:9Pages:2744-2748
Abstract

Semiconducting polymer dots (Pdots) have recently attracted considerable attention because of their photocatalytic activity as well as tunable optical band gap. In this contribution, we describe the therapeutic application of Pdots through in situ photocatalytic hydrogen generation. Liposomes were employed as nanoreactors to confine the Pdot photocatalyst, reactants, intermediates, and by‐products. Upon photon absorption by the Pdots, the catalytic cycle is initiated and repeated within the aqueous interior, while the H2 product diffuses across the lipid bilayer to counteract reactive oxygen species (ROS) overexpressed in diseased tissues. Ensemble and single‐particle Förster resonance energy transfer microscopy confirmed the proposed nanoreactor model. We demonstrate that a liposomal nanoreactor containing Pdots and a sacrificial electron donor is a potential photocatalytic nanoreactor for in situ hydrogen therapy.

KeywordCompartmentalization Hydrogen Therapy Liposomes Photocatalysis Polymer Dots
DOI10.1002/anie.201813066
Indexed BySCI
Language英语
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
WOS IDWOS:000459807200031
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Cited Times [WOS]:13   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionINSTITUTE OF COLLABORATIVE INNOVATION
Faculty of Health Sciences
Corresponding AuthorChangfeng Wu; Xuanjun Zhang
Affiliation1.Faculty of Health Sciences, University of Macau, Macau SAR, China
2.College of Medical Laboratory, Dalian Medical University, Dalian, Liaoning, 116044 China
3.Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen, Guangdong, 518055 China
4.Paul C. Lauterbur Research Center for Biomedical Imaging, Institute of Biomedical and Health Engineering, Shenzhen Institute of Advanced Technology, Chinese Academy of Science, Shenzhen, 518055 China
First Author AffilicationFaculty of Health Sciences
Corresponding Author AffilicationFaculty of Health Sciences
Recommended Citation
GB/T 7714
Boyu Zhang,Fei Wang,Hua Zhou,et al. Polymer Dots Compartmentalized in Liposomes as a Photocatalyst for In Situ Hydrogen Therapy[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2019,58(9):2744-2748.
APA Boyu Zhang.,Fei Wang.,Hua Zhou.,Duyang Gao.,Zhen Yuan.,...&Xuanjun Zhang.(2019).Polymer Dots Compartmentalized in Liposomes as a Photocatalyst for In Situ Hydrogen Therapy.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,58(9),2744-2748.
MLA Boyu Zhang,et al."Polymer Dots Compartmentalized in Liposomes as a Photocatalyst for In Situ Hydrogen Therapy".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 58.9(2019):2744-2748.
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