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Meta-analysis of adherence to highly active antiretroviral therapy in patients with HIV infection in China
Yuan-Yuan Wang1,2; Yu Jin2; Chang Chen2; Wei Zheng3; Shi-Bin Wang4,5; Gabor S. Ungvari6,7; Chee H. Ng8; Xiaohua Douglas Zhang2; Gang Wang9,10,11; Yu-Tao Xiang2
2019-08
Source PublicationAIDS CARE-PSYCHOLOGICAL AND SOCIO-MEDICAL ASPECTS OF AIDS/HIV
ISSN0954-0121
Volume31Issue:8Pages:913-922
Abstract

With the widespread implementation of antiretroviral therapy in many countries, the HIV/AIDS epidemic has declined. However, little is known about the prevalence of adherence rate to Highly Active Antiretroviral Therapy (HAART) in patients with HIV infection in China. This is the first meta-analysis of cross-sectional studies of treatment adherence (≥ 95%) to HAART in Chinese patients. Both English (PubMed, PsycINFO, EMBASE, and Web of Science) and Chinese (WanFang, CNKI, and SinoMed) databases were systematically and independently searched by three investigators. Studies with adherence rate estimates of HAART were included. Adherence rate estimates of each eligible study were extracted and pooled using the random-effects model. A total of 40 studies conducted in China were eligible and analyzed. The mean rate of ≥ 95% adherence to HAART was 81.1% (95%CI: 75.1%–88.0%, I2 = 97.3%) at one week, 80.9% (95%CI: 74.7%–85.9%, I2 = 96.6%) at one month, and 68.3% (95%CI: 46.1%–84.4%, I2 = 97.1%) at 3 months or longer. Subgroup analyses revealed that samples with no gender predominance, low education level, middle economic region, rural area, older age (42.3 years), and recent publication (2013 or later) were correlated to higher HAART adherence. The average rate of HAART adherence was relatively high in China, which indicates effective HIV/AIDS policy, prevention and control measures. However, the HAART adherence rate decreased over the study time period.

KeywordHiv Highly Active Antiretroviral Therapy China Meta-analysis Cross-sectional Studies
DOI10.1080/09540121.2018.1554238
Indexed BySCI
Language英语
WOS Research AreaHealth Care Sciences & Services ; Public, Environmental & Occupational Health ; Psychology ; Respiratory System ; Biomedical Social Sciences
WOS SubjectHealth Policy & Services ; Public, Environmental & Occupational Health ; Psychology, Multidisciplinary ; Respiratory System ; Social Sciences, Biomedical
WOS IDWOS:000471180100001
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Cited Times [WOS]:16   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.De Montfort Univ, Fac Hlth & Life Sci, Leicester, Leics, England
2.Univ Macau, Fac Hlth Sci, Inst Translat Med, Unit Psychiat, Macau, Peoples R China
3.Guangzhou Med Univ, Guangzhou Huiai Hosp, Affiliated Brain Hosp, Guangzhou, Guangdong, Peoples R China
4.Guangdong Gen Hosp, Guangdong Mental Hlth Ctr, Guangzhou, Guangdong, Peoples R China
5.Guangdong Acad Med Sci, Guangzhou, Guangdong, Peoples R China
6.Univ Notre Dame, Australia & Graylands Hosp, Perth, WA, Australia
7.Univ Western Australia, Med Sch, Div Psychiat, Perth, WA, Australia
8.Univ Melbourne, Dept Psychiat, Melbourne, Vic, Australia
9.Capital Med Univ, Sch Mental Hlth, Natl Clin Res Ctr Mental Disorders, Beijing, Peoples R China
10.Capital Med Univ, Sch Mental Hlth, Beijing Anding Hosp, Beijing Key Lab Mental Disorders, Beijing, Peoples R China
11.Capital Med Univ, Sch Mental Hlth, Adv Innovat Ctr Human Brain Protect, Beijing, Peoples R China
First Author AffilicationUniversity of Macau
Recommended Citation
GB/T 7714
Yuan-Yuan Wang,Yu Jin,Chang Chen,et al. Meta-analysis of adherence to highly active antiretroviral therapy in patients with HIV infection in China[J]. AIDS CARE-PSYCHOLOGICAL AND SOCIO-MEDICAL ASPECTS OF AIDS/HIV,2019,31(8):913-922.
APA Yuan-Yuan Wang.,Yu Jin.,Chang Chen.,Wei Zheng.,Shi-Bin Wang.,...&Yu-Tao Xiang.(2019).Meta-analysis of adherence to highly active antiretroviral therapy in patients with HIV infection in China.AIDS CARE-PSYCHOLOGICAL AND SOCIO-MEDICAL ASPECTS OF AIDS/HIV,31(8),913-922.
MLA Yuan-Yuan Wang,et al."Meta-analysis of adherence to highly active antiretroviral therapy in patients with HIV infection in China".AIDS CARE-PSYCHOLOGICAL AND SOCIO-MEDICAL ASPECTS OF AIDS/HIV 31.8(2019):913-922.
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