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Molecular Engineering of Near-Infrared Light-Responsive BODIPY-Based Nanoparticles with Enhanced Photothermal and Photoacoustic Efficiencies for Cancer Theranostics
Duyang Gao1,2; Boyu Zhang1,3; Yubin Liu1; Dehong Hu2; Zonghai Sheng2; Xuanjun Zhang1; Zhen Yuan1
2019
Source PublicationTheranostics
ISSN1838-7640
Volume9Issue:18Pages:5315-5331
Abstract

Background: Engineering a single organic-molecule-based nanoparticle integrating precise diagnosis and effective therapy is of great significance for cancer treatment and future clinical applications but remains a great challenge. The goal of this study is to explore small organic molecule-based nanoparticles with high photothermal conversion efficiency for photoacoustic imaging-guided therapy.

Methods: Heptacyclic B, O-chelated BODIPY structure (namely Boca-BODIPY) with strong near-infrared (NIR) absorption was designed as a theranostic agent through simply molecular engineering, in which heavy atoms and alkyl chains were introduced to promote its application for tumor theranostics. The Boca-BODIPY molecules are further encapsulated in reduced bovine serum albumin (BSA) through self-assembly.

Results: The BSA-Boca-BODIPY exhibited excellent biocompatibility, extraordinary stability and high photothermal conversion efficiency up to 58.7%. The nanoparticles could dramatically enhance photoacoustic contrast of the tumor region, and the signal-to-noise ratio was increased about 14 times at 10 h post intravenous injection in 4T1 tumor-bearing mice. In addition, the nanoassemblies can efficiently convert laser energy (808 nm, 0.75 w cm-2, 5min) into hyperthermia for tumor ablation. Under the photoacoustic imaging-guided photothermal therapy (PTT), the 4T1 cancer cells were efficiently killed, no tumor recurrence and PTT-induced toxicity is observed.

Conclusions: Molecular engineering is a promising way to design organic-molecule-based nanoparticles for cancer theranostics. Other organic-molecule-based nanoparticles which show great promise for imaging-guided cancer precision therapy can be engineered through this method.

KeywordBodipy Molecular Engineering Photoacoustic Imaging Photothermal Therapy Near-infrared Absorption Theragnostic Nanoparticles
DOI10.7150/thno.34418
Indexed BySCI
Language英语
WOS Research AreaResearch & Experimental Medicine
WOS SubjectMedicine, Research & Experimental
WOS IDWOS:000474899500013
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Cited Times [WOS]:5   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionINSTITUTE OF COLLABORATIVE INNOVATION
Faculty of Health Sciences
Corresponding AuthorZonghai Sheng; Xuanjun Zhang; Zhen Yuan
Affiliation1.Faculty of Health Sciences, University of Macau, Macau SAR, 999078, PR China
2.Paul C. Lauterbur Research Center for Biomedical Imaging, Institute of Biomedical and Health Engineering, Shenzhen Key Laboratory of Ultrasound Imaging and Therapy, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China
3.College of Medical Laboratory, Dalian Medical University, No. 9 West Section LvShun South Road, Dalian 116044, P. R. China
First Author AffilicationFaculty of Health Sciences
Corresponding Author AffilicationFaculty of Health Sciences
Recommended Citation
GB/T 7714
Duyang Gao,Boyu Zhang,Yubin Liu,et al. Molecular Engineering of Near-Infrared Light-Responsive BODIPY-Based Nanoparticles with Enhanced Photothermal and Photoacoustic Efficiencies for Cancer Theranostics[J]. Theranostics,2019,9(18):5315-5331.
APA Duyang Gao.,Boyu Zhang.,Yubin Liu.,Dehong Hu.,Zonghai Sheng.,...&Zhen Yuan.(2019).Molecular Engineering of Near-Infrared Light-Responsive BODIPY-Based Nanoparticles with Enhanced Photothermal and Photoacoustic Efficiencies for Cancer Theranostics.Theranostics,9(18),5315-5331.
MLA Duyang Gao,et al."Molecular Engineering of Near-Infrared Light-Responsive BODIPY-Based Nanoparticles with Enhanced Photothermal and Photoacoustic Efficiencies for Cancer Theranostics".Theranostics 9.18(2019):5315-5331.
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