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TSA restores hair follicle-inductive capacity of skin-derived precursors
Ling Guo1,3; Xiaoxiao Wang1,2,3; Jifan Yuan3; Meishu Zhu4; Xiaobing Fu5,6; Ren-He Xu7; Chuanyue Wu8; Yaojiong Wu1,2

The genesis of the hair follicle relies on signals derived from mesenchymal cells in the dermis during skin morphogenesis and regeneration. Multipotent skin-derived precursors (SKPs), which exhibit long term proliferation potential when being cultured in spheroids, have been shown to induce hair genesis and hair follicle regeneration in mice, implying a therapeutic potential of SKPs in hair follicle regeneration and bioengineering. However, the hair-inductive property of SKPs declines progressively upon ex vivo culture expansion, suggesting that the expressions of the genes responsible for hair induction are epigenetically unstable. In this study, we found that TSA markedly alleviated culture expansion induced SKP senescence, increased the expression and activity of alkaline phosphatase (AP) in the cells and importantly restored the hair inductive capacity of SKPs. TSA increased the acetylation level of histone H3, including the K19/14 sites in the promoter regions of bone morphogenetic proteins (BMPs) genes, which were associated with elevated gene expression and BMP signaling activity, suggesting a potential attribution of BMP pathway in TSA induced recovery of the hair inductive capacity of SKPs.

Indexed BySCIE
WOS Research AreaScience & Technology - Other Topics
WOS SubjectMultidisciplinary Sciences
WOS IDWOS:000459799800016
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Cited Times [WOS]:2   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Corresponding AuthorChuanyue Wu; Yaojiong Wu
Affiliation1.State Key Laboratory of Chemical Oncogenomics, and the the Shenzhen Key Laboratory of Health Sciences and Technology, Graduate School at Shenzhen, Tsinghua University, Shenzhen, China
2.Tsinghua-Berkeley Shenzhen Institute (TBSI), Tsinghua University, Shenzhen, China
3.Guangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research, Shenzhen Key Laboratory of Cell Microenvironment, and Department of Biology, Academy for Advanced Interdisciplinary Studies, Southern University of Science and Technology, Shenzhen, China
4.Shenzhen Second People’s Hospital (The First Hospital Affiliated to Shenzhen University), Shenzhen, China
5.Wound Healing and Cell Biology Laboratory, Institute of Basic Medical Science, Chinese PLA General Hospital, Beijing, China
6.Stem Cell and Tissue Regeneration Laboratory, The First Affiliated Hospital, General Hospital of PLA, Beijing, China
7.University of Macau, Institute of Translational Medicine, and Centre of Reproduction, Development and Aging, Faculty of Health Sciences, Taipa, Macau, China
8.Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15261, USA
Recommended Citation
GB/T 7714
Ling Guo,Xiaoxiao Wang,Jifan Yuan,et al. TSA restores hair follicle-inductive capacity of skin-derived precursors[J]. SCIENTIFIC REPORTS,2019,9.
APA Ling Guo.,Xiaoxiao Wang.,Jifan Yuan.,Meishu Zhu.,Xiaobing Fu.,...&Yaojiong Wu.(2019).TSA restores hair follicle-inductive capacity of skin-derived precursors.SCIENTIFIC REPORTS,9.
MLA Ling Guo,et al."TSA restores hair follicle-inductive capacity of skin-derived precursors".SCIENTIFIC REPORTS 9(2019).
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