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Engineering biocompatible benzodithiophene-based polymer dots with tunable absorptions as high-efficiency theranostic agents for multiscale photoacoustic imaging-guided photothermal therapy
Kaiwen Chang1,2; Duyang Gao1; Qiaofang Qi2; Yubin Liua1; Zhen Yuan1
2019-05
Source PublicationBIOMATERIALS SCIENCE
ISSN2047-4830
Volume7Issue:4Pages:1486-1492
Abstract

To date, photoacoustic imaging (PAI) and PAI-guided photothermal therapy (PTT) have been performed for noninvasive cancer diagnosis and precise ablation of tumors. To conduct concurrent PAI and PTT, it is essential to develop theranostic agents with strong optical absorption and high photothermal transfer efficiency. In this study, we have engineered theranostic agents with tunable absorptions based on conjugated polymer dots (Pdots) with different structures via the simple precipitation method. The as-synthesized Pdots exhibit strong absorption, high biocompatibility, and superior stability. In addition, the Pdots demonstrate that they can serve as contrast agents for multiscale PAI in vitro and in vivo. More importantly, a high photothermal conversion efficiency up to 40% is reached under irradiation with LED light, resulting in effective cancer treatment with extremely low light dose. Consequently, they show the potential as imaging-guided therapeutic agents for clinical cancer treatment and various biomedical applications.

DOI10.1039/c8bm01577e
Indexed BySCIE
Language英语
WOS Research AreaMaterials Science
WOS SubjectMaterials Science, bioMaterials
WOS IDWOS:000463746600020
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Cited Times [WOS]:4   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
INSTITUTE OF COLLABORATIVE INNOVATION
Corresponding AuthorZhen Yuan
Affiliation1.Bioimaging Core, Faculty of Health Sciences, University of Macau, Macau SAR 999078, China
2.Key Laboratory of Medical Molecular Probes, Department of Chemistry, School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang 453003, Henan, China
First Author AffilicationFaculty of Health Sciences
Corresponding Author AffilicationFaculty of Health Sciences
Recommended Citation
GB/T 7714
Kaiwen Chang,Duyang Gao,Qiaofang Qi,et al. Engineering biocompatible benzodithiophene-based polymer dots with tunable absorptions as high-efficiency theranostic agents for multiscale photoacoustic imaging-guided photothermal therapy[J]. BIOMATERIALS SCIENCE,2019,7(4):1486-1492.
APA Kaiwen Chang,Duyang Gao,Qiaofang Qi,Yubin Liua,&Zhen Yuan.(2019).Engineering biocompatible benzodithiophene-based polymer dots with tunable absorptions as high-efficiency theranostic agents for multiscale photoacoustic imaging-guided photothermal therapy.BIOMATERIALS SCIENCE,7(4),1486-1492.
MLA Kaiwen Chang,et al."Engineering biocompatible benzodithiophene-based polymer dots with tunable absorptions as high-efficiency theranostic agents for multiscale photoacoustic imaging-guided photothermal therapy".BIOMATERIALS SCIENCE 7.4(2019):1486-1492.
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