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Emotion recognition and its relation to prefrontal function and network in heroin plus nicotine dependence: a pilot study
Hada Fong-ha Ieong; Zhen Yuan
2018-04
Source PublicationNEUROPHOTONICS
ISSN2329-423X
Volume5Issue:2
Abstract

Many patients with substance use disorders (SUDs) live in a stressful environment, and comorbidity is not uncommon. Understanding the neural mechanisms underlying heroin and nicotine dependences and their relationships to social cognition could facilitate behavioral therapy efficacy. We aimed to provide a translational approach that leads to identifying potential biomarkers for opioid use disorder (OUD) susceptibility during recovery. We examined the clinical characters and the relationships between theory of mind (ToM) and executive functions in three groups: heroin plus nicotine-dependent (HND) patients who had remained heroin abstinent (>= 3 months), nicotine-dependent (ND) subjects, and healthy controls (C). The domains included emotion recognition, inhibition, shifting, updating, access, and processing speed. Resting-state functional connectivity (rsFC), ToM task-induced functional connectivity, and brain networks were then explored among 21 matched subjects using functional near-infrared spectroscopy. HND enhanced the severities of anxiety, depression, and hyperactivity. Inhibition domain was impaired in both HND and ND. No impairment in domains of emotion recognition, access, and update was observed. HND demonstrated enhanced rsFC in the medial prefrontal cortex and orbitofrontal cortex (OFC) and decreased ToM-induced connectivity across the PFC. The right superior frontal gyrus in the OFC (oSFG; x = 22, y = 77, and z = 6) was associated with working memory and emotion recognition in HND. Using a neuroimaging tool, these results supported the prominent reward-deficit-and-stress-surfeit hypothesis in SUDs, especially OUD, after protracted withdrawal. This may provide an insight in identifying potential biomarkers related to a dynamic environment.

KeywordOpiate Addiction Functional Near-infrared Spectroscopy Graph Theory Resting-state Functional Connectivity Tobacco Translational Medicine
DOI10.1117/1.NPh.5.2.025011
Indexed BySCIE ; SSCI
Language英语
WOS Research AreaNeurosciences & Neurology ; Optics
WOS SubjectNeurosciences ; Optics
WOS IDWOS:000438894900011
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Cited Times [WOS]:5   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
INSTITUTE OF COLLABORATIVE INNOVATION
Corresponding AuthorZhen Yuan
AffiliationUniversity of Macau, Bioimaging Core, Faculty of Health Sciences, Macau SAR, China
First Author AffilicationFaculty of Health Sciences
Corresponding Author AffilicationFaculty of Health Sciences
Recommended Citation
GB/T 7714
Hada Fong-ha Ieong,Zhen Yuan. Emotion recognition and its relation to prefrontal function and network in heroin plus nicotine dependence: a pilot study[J]. NEUROPHOTONICS,2018,5(2).
APA Hada Fong-ha Ieong,&Zhen Yuan.(2018).Emotion recognition and its relation to prefrontal function and network in heroin plus nicotine dependence: a pilot study.NEUROPHOTONICS,5(2).
MLA Hada Fong-ha Ieong,et al."Emotion recognition and its relation to prefrontal function and network in heroin plus nicotine dependence: a pilot study".NEUROPHOTONICS 5.2(2018).
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