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Semiconducting polymer dot as a highly-effective contrast agent for photoacoustic imaging
Zhen Yuan; Jian Zhang
2018
Conference NameConference on Photons Plus Ultrasound - Imaging and Sensing
Source PublicationPHOTONS PLUS ULTRASOUND: IMAGING AND SENSING 2018
Volume10494
Conference DateJAN 28-FEB 01, 2018
Conference PlaceSan Francisco, CA
Abstract

In this study, we developed a novel PIID-DTBT based semiconducting polymer dots (Pdots) that have broad and strong optical absorption in the visible-light region (500 nm - 700 nm). Gold nanoparticles (GNPs) and gold nanorods (GNRs) that have been verified as an excellent photoacoustic contrast agent were compared with Pdots based on photoacoustic imaging method. Both ex vivo and in vivo experiment demonstrated Pdots have a better photoacoustic conversion efficiency at 532 nm than GNPs and similar photoacoustic performance with GNRs at 700 nm at the same mass concentration. Our work demonstrates the great potential of Pdots as a highly effective contrast agent for precise localization of lesions relative to the blood vessels based on photoacoustic tomography imaging.

KeywordPhotoacoustic Imaging Polymer Dots
DOI10.1117/12.2286796
Indexed ByCPCI
Language英语
WOS Research AreaMicroscopy ; Optics ; Radiology, Nuclear Medicine & Medical Imaging
WOS SubjectMicroscopy ; Optics ; Radiology, Nuclear Medicine & Medical Imaging
WOS IDWOS:000453069300061
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Citation statistics
Document TypeConference paper
CollectionFaculty of Health Sciences
INSTITUTE OF COLLABORATIVE INNOVATION
AffiliationUniversity of Macau, Bioimaging Core, Faculty of Health Sciences, Macau SAR, China
First Author AffilicationFaculty of Health Sciences
Recommended Citation
GB/T 7714
Zhen Yuan,Jian Zhang. Semiconducting polymer dot as a highly-effective contrast agent for photoacoustic imaging[C],2018.
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