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Novel Findings from Determination of Common Expressed Plasma Exosomal microRNAs in Patients with Psoriatic Arthritis, Psoriasis Vulgaris, Rheumatoid Arthritis, and Gouty Arthritisw
Xiu-Min Chen1,2; Yue Zhao1; Xiao-Dong Wu1; Mao-Jie Wang1,3; Hua Yu4; Jin-Jian Lu4; Yuan-Jia Hu4; Qing-Chun Huang1,2; Run-Yue Huang1,5; Chuan-Jian Lu1,5
2019-07
Source PublicationDISCOVERY MEDICINE
ISSN1539-6509
Volume28Issue:151Pages:47-68
Abstract

Background: Circulating exosomal microRNAs modulate not only cancer cell metabolism but also the immune response, and therefore plasma exosomal microRNAs might have the potential to be the biomarkers for a number of immune disorders. Objective: This study was conducted to identify the common mechanisms among psoriatic arthritis (PsA), psoriasis vulgaris (PV), rheumatoid arthritis (RA), and gouty arthritis (GA). The common expressed plasma exosomal microRNAs in these diseases were determined. Methods: The expression of microRNAs derived from plasma exosome of patients with PsA (n=30), PV (n=15), RA (n=15), GA (n=15), and healthy controls (n=15) was evaluated via sequencing. Function analysis of common expressed microRNAs was conducted by the Gene ontology (GO) and Kyoto encyclopedia of genes and genomes (KEGG) enrichment analyses. Coexpression analysis was conducted to identify novel and significant genes and proteins by using the Search Tool for the Retrieval of Interacting Genes (STRING). A systematic literature review was conducted to uncover the role of the common microRNAs in the pathogenesis of PsA, PV, RA, and GA. Results: A total of 36 common expressed microRNAs were detected in patients with PsA, PV, RA, and GA. The most significantly enriched biological processes, cellular components, and molecular functions were "homophilic cell adhesion via plasma membrane adhesion molecules," "CCR4-NOT complex," and "calcium ion binding," respectively. "Antigen processing and presentation" was the most significantly enriched pathway. A total of 91 validated coexpressed gene pairs were identified and 16 common expressed microRNAs and 85 potential target genes were screened based on Cytoscape. Of 36 common expressed microRNAs, 5 microRNAs, including hsa-miR-151a-3p, hsa-miR-199a-5p, hsa-miR-370-3p, hsa-miR-589-5p, and hsa-miR-769-5p, were considered to be connected with the common pathogenesis of PsA, PV, RA, and GA. Systemic review revealed that the roles of these 5 microRNAs are related to immune disorder and bone injury, which matches the conclusion from GO and KEGG analyses. Conclusion: (1) Both immune disorder and bone metabolic dysregulation could be the shared mechanism in the development of PsA, PV, RA, and GA. (2) Immune dysfunction is involved in GA. Our study may shed new light on the diagnosis and treatment strategy of these autoimmune diseases and GA, which warrants further studies.

Language英语
WOS Research AreaResearch & Experimental Medicine
WOS SubjectMedicine, Research & Experimental
WOS IDWOS:000486579700005
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Cited Times [WOS]:2   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorRun-Yue Huang; Chuan-Jian Lu
Affiliation1.Guangzhou Univ Chinese Med, Affiliated Hosp 2, Guangdong Prov Hosp Chinese Med, Guangzhou 510120, Guangdong, Peoples R China
2.Guangdong Prov Key Lab Chinese Med Prevent & Trea, Guangzhou 510120, Guangdong, Peoples R China
3.Univ Med Ctr Utrecht, Utrecht, Netherlands
4.Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Taipa, Macao, Peoples R China
5.Guangdong Prov Key Lab Clin Res Tradit Chinese Me, Guangzhou 510120, Guangdong, Peoples R China
Recommended Citation
GB/T 7714
Xiu-Min Chen,Yue Zhao,Xiao-Dong Wu,et al. Novel Findings from Determination of Common Expressed Plasma Exosomal microRNAs in Patients with Psoriatic Arthritis, Psoriasis Vulgaris, Rheumatoid Arthritis, and Gouty Arthritisw[J]. DISCOVERY MEDICINE,2019,28(151):47-68.
APA Xiu-Min Chen.,Yue Zhao.,Xiao-Dong Wu.,Mao-Jie Wang.,Hua Yu.,...&Chuan-Jian Lu.(2019).Novel Findings from Determination of Common Expressed Plasma Exosomal microRNAs in Patients with Psoriatic Arthritis, Psoriasis Vulgaris, Rheumatoid Arthritis, and Gouty Arthritisw.DISCOVERY MEDICINE,28(151),47-68.
MLA Xiu-Min Chen,et al."Novel Findings from Determination of Common Expressed Plasma Exosomal microRNAs in Patients with Psoriatic Arthritis, Psoriasis Vulgaris, Rheumatoid Arthritis, and Gouty Arthritisw".DISCOVERY MEDICINE 28.151(2019):47-68.
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