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Siegesbeckia Orientalis L. Extract Attenuates Postoperative Cognitive Dysfunction, Systemic Inflammation, and Neuroinflammation
John Man Tak Chu2; Wei Xiong1,2; Ke Gang Linghu1; Yan Liu2; Yan Zhang2; Guan Ding Zhao1; Michael G. Irwin2; Gordon Tin Chun Wong2; Hua Yu1,3,4
2018-12
Source PublicationEXPERIMENTAL NEUROBIOLOGY
ISSN1226-2560
Volume27Issue:6Pages:564-573
Abstract

A proportion of patients experience acute or even prolonged cognitive impairment after surgery, a condition known as postoperative cognitive dysfunction (POCD). It is characterized by impairment in different cognitive domains and neuroinflammation has been implicated as one of the inciting factors as strategies targeting inflammation tend to improve cognitive performance. Siegesbeckia Orientails L. (S. Orientails) is a common Chinese medicinal herb used for managing chronic inflammatory diseases. We investigated if pretreatment with S. Orientails before surgery confers any neuroprotective effects in postoperative animals in terms of reducing inflammation and mitigating cognitive impairment. Three-month-old male C57BL/6N mice were fed different doses of S. Orientails extract for 14 days before they underwent a laparotomy. After cognitive testing they were sacrificed on postoperative day (POD) 3. Our results showed that animals with extract pretreatment demonstrated memory improvement in a dose-dependent manner compared with control. Further, evidence for the attenuation of systemic and neuroinflammation was found in the pretreated animals, along with the inhibition of inflammatory pathways and significantly reduced tau phosphorylation in the hippocampus. Taken together, these results demonstrated a neuroprotective effect of S. Orientails in postoperative animals, indicating a therapeutic potential of S. Orientails in minimizing POCD and the possibility of utilizing this traditional Chinese medicine perioperatively.

KeywordSurgery Cognitive Dysfunction Inflammation Tau
DOI10.5607/en.2018.27.6.564
Indexed BySCIE
Language英语
WOS Research AreaResearch & Experimental Medicine ; Neurosciences & Neurology
WOS SubjectMedicine, Research & Experimental ; Neurosciences
WOS IDWOS:000455091900008
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Cited Times [WOS]:4   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorGordon Tin Chun Wong; Hua Yu
Affiliation1.Institute of Chinese Medical Sciences, State Key Laboratory of Quality Research in Chinese Medicine, University of Macau, Macao SAR 999078, China
2.Department of Anaesthesiology, LKS Faculty of Medicine, The University of Hong Kong, Pokfulam 999077, Hong Kong, China
3.HKBU Shenzhen Research Center, Shenzhen 518000, Guangdong, China
4.School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong 999077, Hong Kong, China
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
John Man Tak Chu,Wei Xiong,Ke Gang Linghu,et al. Siegesbeckia Orientalis L. Extract Attenuates Postoperative Cognitive Dysfunction, Systemic Inflammation, and Neuroinflammation[J]. EXPERIMENTAL NEUROBIOLOGY,2018,27(6):564-573.
APA John Man Tak Chu.,Wei Xiong.,Ke Gang Linghu.,Yan Liu.,Yan Zhang.,...&Hua Yu.(2018).Siegesbeckia Orientalis L. Extract Attenuates Postoperative Cognitive Dysfunction, Systemic Inflammation, and Neuroinflammation.EXPERIMENTAL NEUROBIOLOGY,27(6),564-573.
MLA John Man Tak Chu,et al."Siegesbeckia Orientalis L. Extract Attenuates Postoperative Cognitive Dysfunction, Systemic Inflammation, and Neuroinflammation".EXPERIMENTAL NEUROBIOLOGY 27.6(2018):564-573.
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