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Prenylflavonoids sanggenon C and kuwanon G from mulberry (Morus alba L.) as potent broad-spectrum bacterial beta-glucuronidase inhibitors: Biological evaluation and molecular docking studies
Bin Wei1; Wei Yang1; Zhi-Xiang Yan1; Qing-Wen Zhang1; Ru Yan1,2
2018-09
Source PublicationJOURNAL OF FUNCTIONAL FOODS
ISSN1756-4646
Volume48Pages:210-219
Abstract

Gut microbial beta-glucuronidases show varied substrate specificity and inhibition propensity, highlighting the necessity of discovering broad-spectrum beta-glucuronidase inhibitor to meet clinical needs. In this study, two prenylflavonoids sanggenon C (SGC) and kuwanon G (KWG) exhibited strong inhibition on p-nitropheny1-beta-Dglucuronide-hydrolyzing activity in pooled human gut microbiota and eight bacterial isolates, while amoxapine, a previously reported Escherichia coli beta-glucuronidase (EcoGUS) inhibitor, only showed poor inhibition on the pooled samples and relatively selective inhibition on individual strains with incomplete inhibition on Staphylococcus.pasteuri 3110. Both prenylflavonoids exhibited mixed-type inhibition against the recombinant enzymes EcoGUS and S. pasteuri 3110 beta-glucuronidase (SpasGUS). Molecular docking studies predicted phenolic groups of SGC and KWG as key structures interacting with the allosteric site of SpasGUS, while the phenolic hydroxyl (SGC) or benzopyranyl (KWG) group accounts for the hydrogen bond interaction with EcoGUS. The potentials of these broad-spectrum inhibitors in alleviating bacterial beta-glucuronidase-mediated drug toxicity/efficacy warrants further investigation.

KeywordSanggenon c Kuwanon g Human Gut Microbiota Beta-glucuronidase Inhibitor Molecular Docking
Language英语
WOS Research AreaFood Science & Technology ; Nutrition & Dietetics
WOS SubjectFood Science & Technology ; Nutrition & Dietetics
WOS IDWOS:000447573600023
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Cited Times [WOS]:1   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorRu Yan
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macao
2.Zhuhai UM Science & Technology Research Institute, Zhuhai 519080, China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Bin Wei,Wei Yang,Zhi-Xiang Yan,et al. Prenylflavonoids sanggenon C and kuwanon G from mulberry (Morus alba L.) as potent broad-spectrum bacterial beta-glucuronidase inhibitors: Biological evaluation and molecular docking studies[J]. JOURNAL OF FUNCTIONAL FOODS,2018,48:210-219.
APA Bin Wei,Wei Yang,Zhi-Xiang Yan,Qing-Wen Zhang,&Ru Yan.(2018).Prenylflavonoids sanggenon C and kuwanon G from mulberry (Morus alba L.) as potent broad-spectrum bacterial beta-glucuronidase inhibitors: Biological evaluation and molecular docking studies.JOURNAL OF FUNCTIONAL FOODS,48,210-219.
MLA Bin Wei,et al."Prenylflavonoids sanggenon C and kuwanon G from mulberry (Morus alba L.) as potent broad-spectrum bacterial beta-glucuronidase inhibitors: Biological evaluation and molecular docking studies".JOURNAL OF FUNCTIONAL FOODS 48(2018):210-219.
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