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Ethanolic extract of fructus alpinia oxyphylla protects against 6-hydroxydopamine-induced damage of PC12 cells in vitro and dopaminergic neurons in zebrafish
Zai-Jun Zhang1,2; Lorita C. V. Cheang1; Mei-Wei Wang1; Guo-Hui Li3; Ivan K. Chu3; Zhi-Xiu Lin4; Simon M. Y. Lee1
2012
Source PublicationCellular and Molecular Neurobiology
ISSN2724340
Volume32Issue:1Pages:27
Abstract

In an attempt to understand the neuroprotective effect of Fructus Alpinia oxyphylla (AOE) and to elucidate its underlying mechanism of action, the ethanolic extract of AOE was investigated using zebrafish and PC12 cell models. AOE prevented and restored 6-hydroxydopamine (6-OHDA)-induced dopaminergic (DA) neuron degeneration and attenuated a deficit of locomotor activity in a zebrafish (Danio rerio) model of Parkinson's disease (PD). Treatment with AOE increased the viability of 6-OHDAtreated PC12 cells in vitro in a dose-dependent manner by attenuating cellular apoptosis. However, protocatechuic acid (PCA) and chrysin, two known polyphenol components of AOE, could not reproduce the neuroprotective activity of AOE in the PD zebrafish or PC12 cell models. A mechanistic study found that the protective effect of AOE against 6-OHDA-induced neuronal injury involved antiinflammatory action (down-regulation of gene expression of IL-1β and TNF-α) and anti-oxidative action (inhibition of NO production and iNOS expression in PC12 cells). Moreover, the PI3K-AKT pathway might be part of the mechanism of neuroprotection of AOE. The results of this research are expected to provide a scientific rationale for the use of AOE in the treatment of PD. However, it is important that the active components that contribute to the neuroprotective action of AOE are identified and characterized.

KeywordFructus Alpinia Oxyphylla Neuroprotection Parkinson's Disease Pc12 Cell Zebrafish
DOI10.1007/s10571-011-9731-0
URLView the original
Language英语
WOS Research AreaCell Biology ; Neurosciences & Neurology
WOS SubjectCell Biology ; Neurosciences
WOS IDWOS:000299328600004
The Source to ArticleScopus
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Cited Times [WOS]:51   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Av. Padre Toma’s Pereira S.J. Taipa, Macao SAR, China
2.Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine & New Drug Research, Institute of New Drug Research, Jinan University College of Pharmacy, Guangzhou, China
3.Department of Chemistry, The University of Hong Kong, Hong Kong SAR, China
4.School of Chinese Medicine, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong SAR
First Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Zai-Jun Zhang,Lorita C. V. Cheang,Mei-Wei Wang,et al. Ethanolic extract of fructus alpinia oxyphylla protects against 6-hydroxydopamine-induced damage of PC12 cells in vitro and dopaminergic neurons in zebrafish[J]. Cellular and Molecular Neurobiology,2012,32(1):27.
APA Zai-Jun Zhang.,Lorita C. V. Cheang.,Mei-Wei Wang.,Guo-Hui Li.,Ivan K. Chu.,...&Simon M. Y. Lee.(2012).Ethanolic extract of fructus alpinia oxyphylla protects against 6-hydroxydopamine-induced damage of PC12 cells in vitro and dopaminergic neurons in zebrafish.Cellular and Molecular Neurobiology,32(1),27.
MLA Zai-Jun Zhang,et al."Ethanolic extract of fructus alpinia oxyphylla protects against 6-hydroxydopamine-induced damage of PC12 cells in vitro and dopaminergic neurons in zebrafish".Cellular and Molecular Neurobiology 32.1(2012):27.
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