UM  > 中華醫藥研究院
Inhibition of drug-induced seizure development in both zebrafish and mouse models by a synthetic nanoreceptor
Qiaoxian Huang2; Kit Ieng Kuok2; Xiangjun Zhang2; Ludan Yue2; Simon M. Y. Lee2; Jianxiang Zhang1; Ruibing Wang2
2018-06-14
Source PublicationNanoscale
ISSN20403372 20403364
Volume10Issue:22Pages:10333-10336
Abstract

A synthetic nanoreceptor, cucurbit[7]uril (CB[7]), fully encapsulated pentylenetetrazol (PTZ), a seizure-inducing model drug. As a consequence of the encapsulation, the development of PTZ induced convulsion behaviors in both larval zebrafish and mouse models were dramatically alleviated, suggesting that CB[7] holds great neuroprotection potential against neurotoxic drugs for clinical applications.

DOI10.1039/c8nr02041h
URLView the original
Indexed BySCI
WOS Research AreaScience & Technology - Other Topics ; Materials Science ; Physics
WOS SubjectChemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
WOS IDWOS:000434692000002
Fulltext Access
Citation statistics
Cited Times [WOS]:13   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorJianxiang Zhang; Ruibing Wang
Affiliation1.Department of Pharmaceutics, College of Pharmacy, Third Military Medical University, Chongqing 400038, China
2.State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macau SAR, China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Qiaoxian Huang,Kit Ieng Kuok,Xiangjun Zhang,et al. Inhibition of drug-induced seizure development in both zebrafish and mouse models by a synthetic nanoreceptor[J]. Nanoscale,2018,10(22):10333-10336.
APA Qiaoxian Huang.,Kit Ieng Kuok.,Xiangjun Zhang.,Ludan Yue.,Simon M. Y. Lee.,...&Ruibing Wang.(2018).Inhibition of drug-induced seizure development in both zebrafish and mouse models by a synthetic nanoreceptor.Nanoscale,10(22),10333-10336.
MLA Qiaoxian Huang,et al."Inhibition of drug-induced seizure development in both zebrafish and mouse models by a synthetic nanoreceptor".Nanoscale 10.22(2018):10333-10336.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Qiaoxian Huang]'s Articles
[Kit Ieng Kuok]'s Articles
[Xiangjun Zhang]'s Articles
Baidu academic
Similar articles in Baidu academic
[Qiaoxian Huang]'s Articles
[Kit Ieng Kuok]'s Articles
[Xiangjun Zhang]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Qiaoxian Huang]'s Articles
[Kit Ieng Kuok]'s Articles
[Xiangjun Zhang]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.