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Multifunction of chrysin in Parkinson's model: Anti-neuronal apoptosis, neuroprotection via activation of MEF2D, and inhibition of monoamine oxidase-B
Baojian Guo2; Chengyou Zheng2; Wei Cai2; Jiehong Cheng2; Hongyu Wang2; Haitao Li4; Yewei Sun2; Wei Cui3; Yuqiang Wang2; Yifan Han1; Simon Ming-Yuen Lee4; Zaijun Zhang2
2016-07-06
Source PublicationJournal of Agricultural and Food Chemistry
ISSN15205118 00218561
Volume64Issue:26Pages:5324-5333
Abstract

Chrysin, a flavonoid compound existing in several plants, is applied as a dietary supplement because of its beneficial effects on general human health and alleviation of neurological disorders. However, mechanisms underlying neuroprotection of chrysin has not been fully elucidated, and the effects of chrysin on the Parkinson's disease (PD) model in vivo have not been investigated. It is here shown that chrysin protects primary granular neurons against 1-methyl-4-phenylpyridinium ion insult via antiapoptosis by reversing the dysregulated expression of Bcl-2, Bax, and caspase 3. The mechanisms also involved activating transcriptional factor myocyte enhancer factor 2D (MEF2D) via regulation of AKT-GSK3β signaling. In this in vivo model of PD, chrysin rescued the dopaminergic neurons loss and alleviated the decrease in dopamine level induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice. Moreover, chrysin markedly inhibited monoamine oxidase-B activity in vitro and in vivo. In conclusion, chrysin exerts beneficial effects to PD, possibly through multitarget mechanisms including antineuronal apoptosis, activation of the AKT-GSK3β/MEF2D pathway, and inhibition of the MAO-B activity.

KeywordChrysin Mao-b Mef2d Neuroprotection Parkinson's Disease
DOI10.1021/acs.jafc.6b01707
URLView the original
Indexed BySCIE
Language英语
WOS Research AreaAgriculture ; Chemistry ; Food Science & Technology
WOS SubjectAgriculture, Multidisciplinary ; Chemistry, Applied ; Food Science & Technology
WOS IDWOS:000379455500005
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Cited Times [WOS]:11   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.Department of Applied Biology and Chemical Technology, Institute of Modern Chinese Medicine, The Hong Kong Polytechnic University, Hung Hom, Hong Kong, China
2.Institute of New Drug Research and Guangzhou Key Laboratory of Innovative Chemical Drug Research in Cardio-cerebrovascular Diseases, Jinan University College of Pharmacy, Guangzhou, 510632 China
3.School of Medicine, Ningbo University, Zhejiang, 315211 China
4.State Key Laboratory of Quality Research of Chinese Medicine and Institute of Chinese Medical Sciences, University of Macau, Taipa, Macao, China
Recommended Citation
GB/T 7714
Baojian Guo,Chengyou Zheng,Wei Cai,et al. Multifunction of chrysin in Parkinson's model: Anti-neuronal apoptosis, neuroprotection via activation of MEF2D, and inhibition of monoamine oxidase-B[J]. Journal of Agricultural and Food Chemistry,2016,64(26):5324-5333.
APA Baojian Guo.,Chengyou Zheng.,Wei Cai.,Jiehong Cheng.,Hongyu Wang.,...&Zaijun Zhang.(2016).Multifunction of chrysin in Parkinson's model: Anti-neuronal apoptosis, neuroprotection via activation of MEF2D, and inhibition of monoamine oxidase-B.Journal of Agricultural and Food Chemistry,64(26),5324-5333.
MLA Baojian Guo,et al."Multifunction of chrysin in Parkinson's model: Anti-neuronal apoptosis, neuroprotection via activation of MEF2D, and inhibition of monoamine oxidase-B".Journal of Agricultural and Food Chemistry 64.26(2016):5324-5333.
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