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Discovery of novel anti-parkinsonian effect of schisantherin A in in vitro and in vivo
Fei Sa1; Lun Qing Zhang1; Cheong Meng Chong1; Bao Jian Guo2; Sai Li2; Zai Jun Zhang1,2; Ying Zheng1; Pui Man Hoi1; Simon Ming Yuen Lee1
2015-04-03
Source PublicationNeuroscience Letters
ISSN0304-3940
Volume593Pages:7-12
Abstract

Dibenzocyclooctadiene lignans represent a unique group of natural chemical structures, are considered as protectants against neuronal cell death and cognitive impairment in neurological disorders. Among the family of dibenzocyclooctadiene lignan analogs from the fruit of Schisandra chinensis (Turcz.) Baill, neuroprotective potential of schisantherin A (StA) has not yet been characterized. In this study, 1-methyl-4-phenylpyridinium ion (MPP)-incubated SH-SY5Y cells and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated mice were used to study the neuroprotection of StA. Pretreatment with StA significantly inhibited MPP-induced cytotoxicity in SH-SY5Y cells. Moreover, StA conferred significant protection against MPTP-induced loss of TH-positive dopaminergic neurons in a Parkinson's disease (PD) mice model. Structure activity relationship analysis suggested that methylenedioxy, benzoyloxy and methoxyl groups, in the dibenzocyclooctadiene lignan of StA, were probably functionally important to its neuroprotective activity. In addition, Western blotting analysis demonstrated that StA exhibited neuroprotection against MPP through the regulation of two distinct pathways including increasing CREB-mediated Bcl-2 expression and activating PI3K/Akt survival signaling suggesting that StA might be a promising neuroprotective agent for the prevention of PD.

KeywordBcl-2 Dibenzocyclooctadiene Lignans Neuroprotection Schisantherin a
DOIhttps://doi.org/10.1016/j.neulet.2015.03.016
URLView the original
Indexed BySCI
Language英语
WOS Research AreaNeurosciences & Neurology
WOS SubjectNeurosciences
WOS IDWOS:000353604700002
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Cited Times [WOS]:18   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorZai Jun Zhang; Simon Ming Yuen Lee
Affiliation1.State Key Laboratory of Quality Research of Chinese Medicine and Institute of Chinese Medical Sciences, University of Macau, Taipa, Macao, China
2.Institute of New Drug Research, Guangdong Province Key Laboratory of Pharmacodynamic, Constituents of Traditional Chinese Medicine & New Drug Research, College of Pharmacy, Jinan University, Guangdong, China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Fei Sa,Lun Qing Zhang,Cheong Meng Chong,et al. Discovery of novel anti-parkinsonian effect of schisantherin A in in vitro and in vivo[J]. Neuroscience Letters,2015,593:7-12.
APA Fei Sa.,Lun Qing Zhang.,Cheong Meng Chong.,Bao Jian Guo.,Sai Li.,...&Simon Ming Yuen Lee.(2015).Discovery of novel anti-parkinsonian effect of schisantherin A in in vitro and in vivo.Neuroscience Letters,593,7-12.
MLA Fei Sa,et al."Discovery of novel anti-parkinsonian effect of schisantherin A in in vitro and in vivo".Neuroscience Letters 593(2015):7-12.
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