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Pharmacokinetic study and optimal formulation of new anti-parkinson natural compound schisantherin A
Fei Sa1; Bao Jian Guo2; Sai Li2; Zai Jun Zhang1,2; Hok Man Chan1; Ying Zheng1; Simon Ming Yuen Lee1
2015
Source PublicationParkinson's Disease
ISSN2042-0080
Volume2015
Abstract

Our recent studies showed that schisantherin A (StA) is a promising candidate for PD treatment, but the pharmacokinetic profile of StA is largely unknown. The effects of different formulations on the pharmacokinetics and bioavailability of StA were investigated by HPLC equipped with a vacuum degasser, a quaternary pump, a manual sampler, and an ultraviolet detector. The absolute bioavailability of StA in nanoemulsion formulation was significantly increased from 4.3% to 47.3%. To the best of our knowledge, this is the first report of absolute bioavailability for StA in rats and successful increase of bioavailability of StA by nanoemulsion formulation. The pharmacokinetic profiles of StA could be significantly improved by a safe nanoemulsion formulation. This study provides a successful example of advanced delivery system for improving the bioavailability of potential central nervous system (CNS) drug candidate with poor solubility. This novel approach could be an effective alternative solution to overcome the shortcomings of conventional poor drug delivery of CNS drugs. The results of present study not only indicate that StA has potential to be developed as a promising oral therapeutic agent for the management of PD but also shed light on novel way to improve bioavailability of PD drugs.

DOIhttp://dx.doi.org/10.1155/2015/951361
URLView the original
Indexed BySCI
Language英语
WOS Research AreaNeurosciences & Neurology
WOS SubjectClinical Neurology
WOS IDWOS:000355453000001
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Cited Times [WOS]:8   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Corresponding AuthorZai Jun Zhang; Simon Ming Yuen Lee
Affiliation1.State Key Laboratory of Quality Research of Chinese Medicine and Institute of Chinese Medical Sciences, University of Macau, Taipa, Macau
2.Institute of New Drug Research, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine & New Drug Research, College of Pharmacy, Jinan University, Guangdong, China
First Author AffilicationInstitute of Chinese Medical Sciences
Corresponding Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Fei Sa,Bao Jian Guo,Sai Li,et al. Pharmacokinetic study and optimal formulation of new anti-parkinson natural compound schisantherin A[J]. Parkinson's Disease,2015,2015.
APA Fei Sa.,Bao Jian Guo.,Sai Li.,Zai Jun Zhang.,Hok Man Chan.,...&Simon Ming Yuen Lee.(2015).Pharmacokinetic study and optimal formulation of new anti-parkinson natural compound schisantherin A.Parkinson's Disease,2015.
MLA Fei Sa,et al."Pharmacokinetic study and optimal formulation of new anti-parkinson natural compound schisantherin A".Parkinson's Disease 2015(2015).
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