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Herbal Medicine Offered as an Initiative Therapeutic Option for the Management of Hepatocellular Carcinoma
Chen SR1; Qiu HC2; Hu Y1; Wang Y1; Wang YT1
2016-06
Source PublicationPhytotherapy Research
ISSN0951-418X
Volume30Issue:6Pages:863-77
Abstract

Hepatocellular carcinoma (HCC) is a common malignant cancer and is the third leading cause of death worldwide. Effective treatment of this disease is limited by the complicated molecular mechanism underlying HCC pathogenesis. Thus, therapeutic options for HCC management are urgently needed. Targeting the Wnt/β-catenin, Hedgehog, Notch, and Hippo-YAP signaling pathways in cancer stem cell development has been extensively investigated as an alternative treatment. Herbal medicine has emerged as an initiative therapeutic option for HCC management because of its multi-level, multi-target, and coordinated intervention effects. In this article, we summarized the recent progress and clinical benefits of targeting the above mentioned signaling pathways and using natural products such as herbal medicine formulas to treat HCC. Proving the clinical success of herbal medicine is expected to deepen the knowledge on herbal medicine efficiency and hasten the adoption of new therapies.

KeywordHepatocellular Carcinoma Herbal Medicine Chinese Medicine
DOIhttp://dx.doi.org/10.1002/ptr.5594
Indexed BySCI
Language英语
WOS Research AreaPharmacology & Pharmacy
WOS SubjectChemistry, Medicinal ; Pharmacology & Pharmacy
WOS IDWOS:000377261100001
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Cited Times [WOS]:13   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionInstitute of Chinese Medical Sciences
Affiliation1.State Key Laboratory of Quality Research in Chinese Medicine and Institute of Chinese Medical Sciences, University of Macau, Avenida da Universidade, Taipa, Macao, SAR, China.
2.Guangxi Institute of Traditional Medical and Pharmaceutical Sciences and Guangxi Key Laboratory of Traditional Chinese Medicine Quality Standards, Nanning, 530022, China.
First Author AffilicationInstitute of Chinese Medical Sciences
Recommended Citation
GB/T 7714
Chen SR,Qiu HC,Hu Y,et al. Herbal Medicine Offered as an Initiative Therapeutic Option for the Management of Hepatocellular Carcinoma[J]. Phytotherapy Research,2016,30(6):863-77.
APA Chen SR,Qiu HC,Hu Y,Wang Y,&Wang YT.(2016).Herbal Medicine Offered as an Initiative Therapeutic Option for the Management of Hepatocellular Carcinoma.Phytotherapy Research,30(6),863-77.
MLA Chen SR,et al."Herbal Medicine Offered as an Initiative Therapeutic Option for the Management of Hepatocellular Carcinoma".Phytotherapy Research 30.6(2016):863-77.
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