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Apoptotic effects of polyprenylated benzoylphloroglucinol derivatives from the twigs of garcinia multiflora
Liu X.1; Yu T.3; Gao X.-M.1; Zhou Y.1; Qiao C.-F.1; Peng Y.4; Chen S.-L.4; Luo K.Q.3; Xu H.-X.1
2010-08-27
Source PublicationJournal of Natural Products
ISSN15206025 01633864
Volume73Issue:8Pages:1355-1359
Abstract

With bioassay-guided fractionation, five new polyprenylated benzoylphloroglucinol derivatives, garcimultiflorone D (1), 18- hydroxygarcimultiflorone D (2), garcimultiflorone E (3), garcimultiflorone F (4), and isogarcimultiflorone F (5), and five known compounds, guttiferone E (6), guttiferone F (7), aristophenone A (8), isoxanthochymol (9), and morelloflavone (10), were isolated from the acetone extract of the twigs of Garcinia multiflora. The compounds were evaluated for their apoptotic effects against HeLa-C3 cells, which have been genetically engineered to produce a fluorescent biosensor capable of detecting caspase-3 activation. Compounds 1 and 3-9 activate caspase-3 in HeLa-C3 cells within 72 h after treatment at a concentration of 100 μM or lower. In particular, compounds 6, 8, and 9 showed strong apoptosis-inducing effects at a concentration of 25 μM. © 2010 The American Chemical Society and American Society of Pharmacognosy.

DOI10.1021/np100156w
URLView the original
Indexed BySCI
Language英语
WOS Research AreaPlant Sciences ; Pharmacology & Pharmacy
WOS SubjectPlant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS IDWOS:000281181200007
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Cited Times [WOS]:30   [WOS Record]     [Related Records in WOS]
Document TypeJournal article
CollectionFaculty of Health Sciences
Affiliation1.Hong Kong Jockey Club Institute of Chinese Medicine
2.Yunnan Minzu University
3.Nanyang Technological University
4.Chinese Academy of Medical Sciences
Recommended Citation
GB/T 7714
Liu X.,Yu T.,Gao X.-M.,et al. Apoptotic effects of polyprenylated benzoylphloroglucinol derivatives from the twigs of garcinia multiflora[J]. Journal of Natural Products,2010,73(8):1355-1359.
APA Liu X..,Yu T..,Gao X.-M..,Zhou Y..,Qiao C.-F..,...&Xu H.-X..(2010).Apoptotic effects of polyprenylated benzoylphloroglucinol derivatives from the twigs of garcinia multiflora.Journal of Natural Products,73(8),1355-1359.
MLA Liu X.,et al."Apoptotic effects of polyprenylated benzoylphloroglucinol derivatives from the twigs of garcinia multiflora".Journal of Natural Products 73.8(2010):1355-1359.
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